Bacterial defences: mechanisms, evolution and antimicrobial resistance

WPJ Smith, BR Wucher, CD Nadell… - Nature Reviews …, 2023 - nature.com
Throughout their evolutionary history, bacteria have faced diverse threats from other
microorganisms, including competing bacteria, bacteriophages and predators. In response …

Ultra-high-performance liquid chromatography high-resolution mass spectrometry variants for metabolomics research

L Perez de Souza, S Alseekh, F Scossa, AR Fernie - Nature Methods, 2021 - nature.com
Ultra-high-performance liquid chromatography high-resolution mass spectrometry (UHPLC–
HRMS) variants currently represent the best tools to tackle the challenges of complexity and …

Persistence of plant-mediated microbial soil legacy effects in soil and inside roots

SE Hannula, R Heinen, M Huberty, K Steinauer… - Nature …, 2021 - nature.com
Plant-soil feedbacks are shaped by microbial legacies that plants leave in the soil. We tested
the persistence of these legacies after subsequent colonization by the same or other plant …

Genomic and chemical diversity of Bacillus subtilis secondary metabolites against plant pathogenic fungi

HT Kiesewalter, CN Lozano-Andrade, M Wibowo… - Msystems, 2021 - Am Soc Microbiol
Bacillus subtilis produces a wide range of secondary metabolites providing diverse plant
growth-promoting and biocontrol abilities. These secondary metabolites include …

Selective drivers of simple multicellularity

K Tong, GO Bozdag, WC Ratcliff - Current Opinion in Microbiology, 2022 - Elsevier
Highlights•We survey ten key selective drivers favouring the evolution of simple
multicellularity.•The selective drivers of multicellularity depend on both lineage and …

The confluence of big data and evolutionary genome mining for the discovery of natural products

MG Chevrette, A Gavrilidou, S Mantri… - Natural product …, 2021 - pubs.rsc.org
This review covers literature between 2003–2021 The development and application of
genome mining tools has given rise to ever-growing genetic and chemical databases and …

Antiphage small molecules produced by bacteria–beyond protein-mediated defenses

A Hardy, L Kever, J Frunzke - Trends in microbiology, 2023 - cell.com
Bacterial populations face the constant threat of viral predation exerted by bacteriophages
('phages'). In response, bacteria have evolved a wide range of defense mechanisms against …

[HTML][HTML] From genotypes to organisms: State-of-the-art and perspectives of a cornerstone in evolutionary dynamics

S Manrubia, JA Cuesta, J Aguirre, SE Ahnert… - Physics of Life …, 2021 - Elsevier
Understanding how genotypes map onto phenotypes, fitness, and eventually organisms is
arguably the next major missing piece in a fully predictive theory of evolution. We refer to this …

Cryptic specialized metabolites drive Streptomyces exploration and provide a competitive advantage during growth with other microbes

EMF Shepherdson, MA Elliot - Proceedings of the National …, 2022 - National Acad Sciences
Streptomyces bacteria have a complex life cycle that is intricately linked with their
remarkable metabolic capabilities. Exploration is a recently discovered developmental …

Mutational meltdown of putative microbial altruists in Streptomyces coelicolor colonies

Z Zhang, S Shitut, B Claushuis, D Claessen… - Nature …, 2022 - nature.com
In colonies of the filamentous multicellular bacterium Streptomyces coelicolor, a
subpopulation of cells arises that hyperproduces metabolically costly antibiotics, resulting in …