In the mammalian central nervous system, reactive oxygen species (ROS) generation is
counterbalanced by antioxidant defenses. When large amounts of ROS accumulate …

Tissue damage, inflammation or injury of the nervous system may result in chronic
neuropathic pain characterised by increased sensitivity to painful stimuli (hyperalgesia), the …

It is known that transient receptor potential ankyrin 1 (TRPA1) channels, expressed by
nociceptors, contribute to neuropathic pain. Here we show that TRPA1 is also expressed in …

Background Our previous study indicated that reactive oxygen species (ROS) are critically
involved in chronic pain. Sestrin2 (Sesn2), a novel stress-inducible protein, is evidenced to …

Clinical pain is a serious public health issue. Treatment of pain-related suffering requires
knowledge of how pain signals are initially interpreted and subsequently transmitted and …

Chronic alcohol consumption produces painful peripheral neuropathy for which there is no
reliable successful therapy, mainly due to lack of understanding of its pathobiology …

Peroxynitrite (PN; ONOO−) and its reactive oxygen precursor superoxide (SO; O2•−) are
critically important in the development of pain of several etiologies including pain associated …

Despite intense investigation, the mechanisms of the different forms of trigeminal
neuropathic pain remain substantially unidentified. The transient receptor potential ankyrin 1 …

Vitamin C (ascorbic acid) plays an important role in maintaining skin health and can promote
the differentiation of keratinocytes and decrease melanin synthesis, leading to antioxidant …

Not all spinal contusions result in mechanical allodynia, in which non-noxious stimuli
become noxious. The studies presented use the NYU impactor at 12.5 mm drop or the …