Lung cancer immunotherapy: progress, pitfalls, and promises

A Lahiri, A Maji, PD Potdar, N Singh, P Parikh, B Bisht… - Molecular cancer, 2023 - Springer
Lung cancer is the primary cause of mortality in the United States and around the globe.
Therapeutic options for lung cancer treatment include surgery, radiation therapy …

Immune checkpoint inhibitors in cancer therapy

Y Shiravand, F Khodadadi, SMA Kashani… - Current …, 2022 - mdpi.com
The discovery of immune checkpoint proteins such as PD-1/PDL-1 and CTLA-4 represents a
significant breakthrough in the field of cancer immunotherapy. Therefore, humanized …

Toripalimab plus chemotherapy in treatment-naïve, advanced esophageal squamous cell carcinoma (JUPITER-06): A multi-center phase 3 trial

ZX Wang, C Cui, J Yao, Y Zhang, M Li, J Feng, S Yang… - Cancer cell, 2022 - cell.com
Platinum-based chemotherapy is the standard first-line treatment for advanced esophageal
squamous cell carcinoma (ESCC). In this phase 3 study (ClinicalTrial. gov: NCT03829969) …

[HTML][HTML] Society for Immunotherapy of Cancer (SITC) clinical practice guideline on immune checkpoint inhibitor-related adverse events

JR Brahmer, H Abu-Sbeih, PA Ascierto… - … for immunotherapy of …, 2021 - ncbi.nlm.nih.gov
Immune checkpoint inhibitors (ICIs) are the standard of care for the treatment of several
cancers. While these immunotherapies have improved patient outcomes in many clinical …

Cancer immunotherapy update: FDA-approved checkpoint inhibitors and companion diagnostics

JD Twomey, B Zhang - The AAPS journal, 2021 - Springer
Immune checkpoint inhibitors (ICIs) are considered a new standard-of-care across many
cancer indications. This review provides an update on ICIs approved by the Food and Drug …

Toripalimab or placebo plus chemotherapy as first-line treatment in advanced nasopharyngeal carcinoma: a multicenter randomized phase 3 trial

HQ Mai, QY Chen, D Chen, C Hu, K Yang, J Wen, J Li… - Nature medicine, 2021 - nature.com
Gemcitabine-cisplatin (GP) chemotherapy is the standard first-line systemic treatment for
recurrent or metastatic nasopharyngeal carcinoma (RM-NPC). In this international, double …

Tumor mutational burden as a predictor of immunotherapy response: is more always better?

JH Strickler, BA Hanks, M Khasraw - Clinical Cancer Research, 2021 - AACR
Immune checkpoint inhibitors, including antibodies that block programmed cell death protein-
1 (PD-1) and PD-L1, have transformed the management of many cancers. However, the …

Non-small-cell lung cancer in 2022: a review for general practitioners in oncology

H Mithoowani, M Febbraro - Current Oncology, 2022 - mdpi.com
Lung cancer is the leading cause of cancer death in Canada and a significant cause of
morbidity for patients and their loved ones. There have been rapid advances in preventing …

Treatment-related adverse events of PD-1 and PD-L1 inhibitors in clinical trials: a systematic review and meta-analysis

Y Wang, S Zhou, F Yang, X Qi, X Wang, X Guan… - JAMA …, 2019 - jamanetwork.com
Importance Programmed cell death (PD-1) and programmed cell death ligand 1 (PD-L1)
inhibitors have been increasingly used in cancer therapy. Understanding the treatment …

Turning the corner on therapeutic cancer vaccines

RE Hollingsworth, K Jansen - npj Vaccines, 2019 - nature.com
Recent advances in several areas are rekindling interest and enabling progress in the
development of therapeutic cancer vaccines. These advances have been made in target …