In vertebrates, transferrin (Tf) safely delivers iron through circulation to cells. Tf-bound iron is
incorporated through Tf receptor (TfR) 1-mediated endocytosis. TfR1 can mediate cellular …

200 billion red blood cells (RBCs) are produced every day, requiring more than 2× 10 15
iron atoms every second to maintain adequate erythropoiesis. These numbers translate into …

Haemochromatosis is defined as systemic iron overload of genetic origin, caused by a
reduction in the concentration of the iron regulatory hormone hepcidin, or a reduction in …

Iron is a vital trace element for humans, as it plays a crucial role in oxygen transport,
oxidative metabolism, cellular proliferation, and many catalytic reactions. To be beneficial …

Iron is an essential trace element for multicellular organisms and nearly all microorganisms.
Although iron is abundant in the environment, common forms of iron are minimally soluble …

Iron is an essential element that is indispensable for life. The delicate physiological body
iron balance is maintained by both systemic and cellular regulatory mechanisms. The iron …

The liver orchestrates systemic iron balance by producing and secreting hepcidin. Known as
the iron hormone, hepcidin induces degradation of the iron exporter ferroportin to control …

Iron is required for many biological processes but is also toxic in excess; thus, body iron
balance is maintained through sophisticated regulatory mechanisms. The lack of a regulated …

Iron is a constituent of many metalloproteins involved in vital metabolic functions. While
adequate iron supply is critical for health, accumulation of excess iron promotes oxidative …

Iron is an essential element in biology, required for numerous cellular processes. Either too
much or too little iron can be detrimental, and organisms have developed mechanisms for …