Transmissible spongiform encephalopathies (TSEs) are inevitably lethal neurodegenerative
diseases that affect humans and a large variety of animals. The infectious agent responsible …

Human prion diseases can be sporadic, inherited, or acquired by infection. Distinct clinical
and pathological characteristics separate sporadic diseases into three phenotypes …

Individuals infected with prions succumb to brain damage, and prion infections continue to
be inexorably lethal. However, many crucial steps in prion pathogenesis occur in lymphatic …

Alzheimer's disease is the main cause of dementia in elderly people and is becoming an
ever greater problem as societies worldwide age. Treatments that stop or at least effectively …

Prion disease is a unique category of illness, affecting both animals and humans, in which
the underlying pathogenesis is related to a conformational change of a normal, self-protein …

Alzheimer's disease (AD) is one of the categories of neurodegenerative diseases
characterized by a conformational change of a normal protein into a pathological conformer …

Despite the efficacy of current immune‐chemotherapy for treatment of B‐cell non‐H odgkin
lymphoma, a substantial proportion of patients relapse, highlighting the need for new …

Prion diseases are sub-acute neurodegenerative diseases that affect humans and some
domestic and free-ranging animals. Infectious prion agents are considered to comprise …

The design of efficient vectors for vaccine development and cancer gene therapy is an area
of intensive research. Bacteria-based vectors are being investigated as optimal vehicles for …

Prion diseases are fatal infectious neurodegenerative disorders and prototypic
conformational diseases, caused by the conformational conversion of the normal cellular …