By influencing Ca2+ homeostasis in spatially and architecturally distinct neuronal
compartments, the endoplasmic reticulum (ER) illustrates the notion that form and function …

The ongoing epidemics of metabolic diseases and increase in the older population have
increased the incidences of neurodegenerative diseases. Evidence from murine and cell …

Declining insect population sizes are provoking grave concern around the world as insects
play essential roles in food production and ecosystems. Environmental contamination by …

Results: CAP antagonized high-fat diet (HFD)-induced obesity without decreasing energy
intake in mice. HFD suppressed TRPV1 expression and activity in BAT and CAP countered …

Somatic stem cells maintain tissue homeostasis by dynamically adjusting proliferation and
differentiation in response to stress and metabolic cues. Here we identify Ca2+ signalling as …

Defining the molecular targets of insecticides is crucial for assessing their selectivity and
potential impact on environment and health. Two commercial insecticides are now shown to …

Large-scale insecticide application is a primary weapon in the control of insect pests in
agriculture. However, a growing body of evidence indicates that it is contributing to the …

Precise regulation of stem cell activity is crucial for tissue homeostasis and necessary to
prevent overproliferation. In the Drosophila adult gut, high levels of reactive oxygen species …

The endoplasmic reticulum (ER) forms a continuous and dynamic network throughout a
neuron, extending from dendrites to axon terminals, and axonal ER dysfunction is implicated …

The cation channel transient receptor potential vanilloid 4 (TRPV4) is one of the few
identified ion channels that can directly cause inherited neurodegeneration syndromes, but …