[HTML][HTML] A Review on Benzimidazole Heterocyclic Compounds: Synthesis and Their Medicinal Activity Applications

LA Mohammed, MA Farhan, SA Dadoosh… - …, 2023 - thieme-connect.com
Benzimidazole is a heterocyclic compound that contains two nitrogen atoms and is formed
by fusing a benzene ring with an imidazole. Benzimidazole and its derivatives are prepared …

Exploration of Remarkably Potential Multitarget-Directed N-Alkylated-2-(substituted phenyl)-1H-benzimidazole Derivatives as Antiproliferative, Antifungal, and …

NKN Phan, TKC Huynh, HP Nguyen, QT Le… - ACS …, 2023 - ACS Publications
Improving lipophilicity for drugs to penetrate the lipid membrane and decreasing bacterial
and fungal coinfections for patients with cancer pose challenges in the drug development …

Deep learning approach to the discovery of novel bisbenzazole derivatives for antimicrobial effect

T Barcin, MA Yucel, RH Ersan, MA Alagoz… - Journal of Molecular …, 2024 - Elsevier
Because of the growing bacterial resistance to antibiotics, the discovery of new antibiotics is
critical. The search for new antimicrobial drugs that are effective in treating new and existing …

Benzimidazole‐Containing Compounds as Anticancer Agents

U Acar Çevik, A Işik, B Kaya, R Kapavarapu… - …, 2024 - Wiley Online Library
Cancer is the second leading cause of death today and remains a threat to human health.
The advent of multi‐drug resistance and adverse effects make the current first‐line anti …

Facile Synthesis of Benzimidazoles via Oxidative Cyclization of Acyclic Monoterpene Aldehyde with Diamines: Studies on Antimicrobial and in Vivo Evaluation of …

M Vaithiyalingam, R Mohan Kumar… - Chemistry & …, 2023 - Wiley Online Library
Abstract Citral (1a), a bioactive component of Cymbopogon citratus (lemongrass) could be
isolated and semi‐synthetic analogs synthesized with improved therapeutic properties …

2‐Ethenyl Imidazolium Salts: Synthesis, Characterization, and Evaluation as Potential Chemotherapeutics

MS Hobbs, WY Chen, WJ Youngs… - ChemistrySelect, 2024 - Wiley Online Library
As candidates for intravesical exfoliants to treat bladder cancer, we have prepared fourteen
new imidazolium compounds substituted at the 2 position. These compounds were …

Organohalogen chalcones: design, synthesis, ADMET prediction, molecular dynamics study and inhibition effect on acetylcholinesterase and carbonic anhydrase

BO Aydin, DA Anil, Y Demir, MA Alagoz - Molecular Diversity, 2024 - Springer
In an effort to discover potential acetylcholinesterase (AChE) and carbonic anhydrase (CA)
inhibitors, a novel series of organohalogen chalcone derivatives (12–20, 23–30) was …

Synthesis and evaluation of di‐heterocyclic benzazole compounds as potential antibacterial and anti‐biofilm agents against Staphylococcus aureus

MB Aktekin, Z Oksuz, B Turkmenoglu… - Chemical Biology & …, 2024 - Wiley Online Library
Cumulative escalation in antibiotic‐resistant pathogens necessitates the quest for novel
antimicrobial agents, as current options continue to diminish bacterial resistance. Herein, we …

Synthesis, Molecular Docking and Molecular Dynamics Simulation Studies of Some Pyridazinone Derivatives as Lipase Inhibitors

MA Alagöz, İS Doğan, S Sener… - Cumhuriyet Science …, 2022 - csj.cumhuriyet.edu.tr
Human health and illness are dependent on lipases, which play a key role in maintaining
cell integrity, storing fat for energy and serving as signaling molecules. In this study, 4 …

[PDF][PDF] Fluorinated benzimidazole derivatives: In vitro antimicrobial activity

KH Jasim, RH Ersan, R Sadeeq, S Salim… - … & Medicinal Chemistry …, 2023 - acgpubs.org
Given the pharmacological significance of fluorine-containing heterocycles, in the present
paper, a series of benzimidazole having fluoro-benzene moiety within a single molecular …