Unraveling the multidimensional complexities of melanoma has required concerted efforts
by dedicated community of researchers and clinicians battling against this deadly form of …

Aims Subungual melanoma (SUM) is increasingly being treated with conservative surgery.
Consequently, the evaluation of the resection margins has increased in importance …

Preferentially expressed antigen in melanoma (PRAME) is a tumor-associated antigen first
identified in a melanoma patient and found to be expressed in most melanomas as well as …

Background Distinguishing melanocytic pseudonests encountered in lichenoid dermatoses
or lichenoid keratoses from melanoma in situ (MIS) with brisk lichenoid inflammation can …

Melanocytic lesions have always represented a diagnostic challenge for surgical
pathologists. According to the literature, PRAME showed great promise as an …

PRAME (PReferentially expressed Antigen in MElanoma) is a cancer testis antigen that is
frequently expressed in melanoma compared to benign melanocytic proliferations and nevi …

Xeroderma Pigmentosum (XP) is a genetic disorder characterized by photosensitivity,
dyschromia, and high risk of skin cancer. From a clinical and histologic view, it can be …

Nevus spilus, or speckled lentiginous nevus, is a relatively common lesion that presents at
birth or in early childhood. It consists of a background tan patch, which appears similar to a …

Abstract Introduction PReferentially expressed Antigen in MElanoma (PRAME) has shown
utility in differentiating benign from malignant melanocytic neoplasms. In this study, we …

The management of periocular melanoma is fraught with difficulty because of the desire to
conserve tissue while at the same time ensuring complete removal of neoplastic cells …