This review aims to survey the current state of mechanotransduction in vascular smooth
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …

Mechanotransduction, the conversion of physical forces into biochemical signals, is
essential for various physiological processes such as the conscious sensations of touch and …

The breaking of bilateral symmetry in most vertebrates is critically dependent upon the
motile cilia of the embryonic left-right organizer (LRO), which generate a directional fluid …

Primary cilia are solitary, generally non-motile, hair-like protrusions that extend from the
surface of cells between cell divisions. Their antenna-like structure leads naturally to the …

Mechanical stimuli drive many physiological processes, including touch and pain sensation,
hearing, and blood pressure regulation. Mechanically activated (MA) cation channel …

Mechanotransduction has an important role in physiology. Biological processes including
sensing touch and sound waves require as-yet-unidentified cation channels that detect …

The primary cilium is an antenna-like, immotile organelle present on most types of
mammalian cells, which interprets extracellular signals that regulate growth and …

Primary cilia are solitary, non-motile extensions of the centriole found on nearly all nucleated
eukaryotic cells between cell divisions. Only∼ 200–300 nm in diameter and a few …

Several proteins implicated in the pathogenesis of polycystic kidney disease (PKD) localize
to cilia. Furthermore, cilia are malformed in mice with PKD with mutations in TgN737Rpw …

Eukaryotic cilia and flagella, including primary cilia and sensory cilia, are highly conserved
organelles that project from the surfaces of many cells. The assembly and maintenance of …