RNA modifications in cancer
Q Tang, L Li, Y Wang, P Wu, X Hou, J Ouyang… - British journal of …, 2023 - nature.com
Currently, more than 170 modifications have been identified on RNA. Among these RNA
modifications, various methylations account for two-thirds of total cases and exist on almost …
modifications, various methylations account for two-thirds of total cases and exist on almost …
Precision RNA base editing with engineered and endogenous effectors
LS Pfeiffer, T Stafforst - Nature Biotechnology, 2023 - nature.com
RNA base editing refers to the rewriting of genetic information within an intact RNA molecule
and serves various functions, such as evasion of the endogenous immune system and …
and serves various functions, such as evasion of the endogenous immune system and …
RNA editing: Expanding the potential of RNA therapeutics
RNA therapeutics have had a tremendous impact on medicine, recently exemplified by the
rapid development and deployment of mRNA vaccines to combat the COVID-19 pandemic …
rapid development and deployment of mRNA vaccines to combat the COVID-19 pandemic …
Adenosine-to-inosine editing of endogenous Z-form RNA by the deaminase ADAR1 prevents spontaneous MAVS-dependent type I interferon responses
Nucleic acids are powerful triggers of innate immunity and can adopt the Z-conformation, an
unusual left-handed double helix. Here, we studied the biological function (s) of Z-RNA …
unusual left-handed double helix. Here, we studied the biological function (s) of Z-RNA …
MicroRNA-206 in human cancer: mechanistic and clinical perspectives
Abstract MicroRNAs (miRNAs), small non-coding RNAs approximately 20–25 nt in length,
play important roles via directly binding to the corresponding 3′ UTR of target mRNAs …
play important roles via directly binding to the corresponding 3′ UTR of target mRNAs …
ADAR activation by inducing a syn conformation at guanosine adjacent to an editing site
EE Doherty, A Karki, XE Wilcox… - Nucleic acids …, 2022 - academic.oup.com
ADARs (adenosine deaminases acting on RNA) can be directed to sites in the transcriptome
by complementary guide strands allowing for the correction of disease-causing mutations at …
by complementary guide strands allowing for the correction of disease-causing mutations at …
Chemical modifications in RNA: elucidating the chemistry of dsRNA-specific adenosine deaminases (ADARs)
HG Mendoza, PA Beal - Accounts of chemical research, 2023 - ACS Publications
Conspectus The term RNA editing refers to any structural change in an RNA molecule (eg.,
insertion, deletion, or base modification) that changes its coding properties and is not a …
insertion, deletion, or base modification) that changes its coding properties and is not a …
Selective inhibition of ADAR1 using 8-azanebularine-modified RNA duplexes
HG Mendoza, VJ Matos, SH Park, KM Pham… - Biochemistry, 2023 - ACS Publications
Adenosine deaminases acting on RNA (ADARs) are RNA editing enzymes that catalyze the
hydrolytic deamination of adenosine (A) to inosine (I) in dsRNA. In humans, two catalytically …
hydrolytic deamination of adenosine (A) to inosine (I) in dsRNA. In humans, two catalytically …
Structural perspectives on adenosine to inosine RNA editing by ADARs
AJ Fisher, PA Beal - Molecular Therapy-Nucleic Acids, 2024 - cell.com
Adenosine deaminases acting on RNA (ADARs) are enzymes that catalyze the hydrolytic
deamination of adenosine to inosine. The editing feature of ADARs has garnered much …
deamination of adenosine to inosine. The editing feature of ADARs has garnered much …
Tissue-specific temperature dependence of RNA editing levels in zebrafish
Background RNA editing by a denosine d eaminase a cting on R NA (ADAR) occurs in all
metazoans and fulfils several functions. Here, we examined effects of acclimation …
metazoans and fulfils several functions. Here, we examined effects of acclimation …