Genome organization and genomics in Chlamydia: whole genome sequencing increases understanding of chlamydial virulence, evolution, and phylogeny

LDW Luu, V Kasimov, S Phillips, GSA Myers… - Frontiers in cellular …, 2023 - frontiersin.org
The genus Chlamydia contains important obligate intracellular bacterial pathogens to
humans and animals, including C. trachomatis and C. pneumoniae. Since 1998, when the …

The Impact of Lateral Gene Transfer in Chlamydia

H Marti, RJ Suchland, DD Rockey - Frontiers in cellular and infection …, 2022 - frontiersin.org
Lateral gene transfer (LGT) facilitates many processes in bacterial ecology and
pathogenesis, especially regarding pathogen evolution and the spread of antibiotic …

The inclusion membrane protein IncS is critical for initiation of the Chlamydia intracellular developmental cycle

ME Cortina, RC Bishop, BA DeVasure… - PLoS …, 2022 - journals.plos.org
All Chlamydia species are obligate intracellular bacteria that undergo a unique biphasic
developmental cycle strictly in the lumen of a membrane bound compartment, the inclusion …

Chlamydia-containing spheres are a novel and predominant form of egress by the pathogen Chlamydia psittaci

J Scholz, G Holland, M Laue, S Banhart, D Heuer - Mbio, 2024 - journals.asm.org
The egress of intracellular bacteria from host cells and cellular tissues is a critical process
during the infection cycle. This process is essential for bacteria to spread inside the host and …

Homologues of the Chlamydia trachomatis and Chlamydia muridarum inclusion membrane protein IncS are interchangeable for early development but not for …

ME Cortina, I Derré - Msphere, 2023 - Am Soc Microbiol
Chlamydia trachomatis is an obligate intracellular bacterium, which undergoes a biphasic
developmental cycle inside a vacuole termed the inclusion. Chlamydia-specific effector …

Chlamydia trachomatis suppresses host cell store-operated Ca2+ entry and inhibits NFAT/calcineurin signaling

NB Chamberlain, Z Dimond, T Hackstadt - Scientific Reports, 2022 - nature.com
The obligate intracellular bacterium, Chlamydia trachomatis, replicates within a
parasitophorous vacuole termed an inclusion. During development, host proteins critical for …

The formation of Chlamydia-containing spheres, a novel non-lytic egress pathway of the zoonotic pathogen Chlamydia psittaci

J Scholz, G Holland, M Laue, S Banhart, D Heuer - bioRxiv, 2023 - biorxiv.org
Egress of intracellular bacteria from host cells and cellular tissues is a critical process during
the infection cycle. This egress process is essential for bacteria to spread inside the host and …

Murine modeling of menstruation identifies immune correlates of protection during Chlamydia muridarum challenge

LA Lawrence, P Vidal, RS Varughese, ZRT Li… - …, 2024 - pmc.ncbi.nlm.nih.gov
The menstrual cycle influences the risk of acquiring sexually transmitted infections (STIs),
including Chlamydia trachomatis (C. trachomatis), although the underlying immune …

A genome-wide genetic screen identified targets for destabilizing the parasitophorous vacuole of Chlamydia trachomatis

MR Babu Sait, LH Jachmann, M Milivojevic… - bioRxiv, 2024 - biorxiv.org
The bacterial pathogen Chlamydia trachomatis employs the effector CpoS to suppress a
host defense response that aborts intracellular bacterial growth by inducing host cell death …

Genomic profiling and characterization of ocular Chlamydia trachomatis reference strain B/HAR36

E Ghasemian, MJ Holland - Microbiology Resource …, 2024 - Am Soc Microbiol
The human pathogen Chlamydia trachomatis has multiple serovariants that have distinct
organotropisms. We recently revised genomic sequence data linked to ocular reference …