Maintenance of genome stability requires control over the expression of transposable
elements (TEs), whose activity can have substantial deleterious effects on the host …

Piwi interacting RNAs (piRNAs) constitute novel small non-coding RNA molecules of
approximately 24–31 nucleotides in length that often bind to members of the piwi protein …

The ENCODE project has reported that at least 80% of the human genome is biologically
active, yet only a small part of human DNA encodes for protein. The massive amount of RNA …

Although non-coding RNAs have long been considered as non-functional “junk” RNAs,
accumulating evidence in the past decade indicates that they play a critical role in …

Nuclear small RNA pathways safeguard genome integrity by establishing transcription-
repressing heterochromatin at transposable elements. This inevitably also targets the …

In animals, small RNA molecules termed PIWI-interacting RNAs (piRNAs) silence
transposable elements (TEs), protecting the germline from genomic instability and mutation …

Extracellular microRNAs (miRNAs) and other small RNAs are implicated in cellular
communication and may be useful as disease biomarkers. We systematically compared …

Summary piRNAs (Piwi-interacting small RNAs) engage Piwi Argonautes to silence
transposons and promote fertility in animal germlines. Genetic and computational studies …

The discovery of various noncoding RNAs (ncRNAs) and their biological implications is a
growing area in cell biology. Increasing evidence has revealed canonical and noncanonical …

RNA decay plays a crucial role in post-transcriptional regulation of gene expression. Work
conducted over the last decades has defined the major mRNA decay pathways, as well as …