State of the art on microbubble cavitation monitoring and feedback control for blood-brain-barrier opening using focused ultrasound
P Mondou, S Mériaux, F Nageotte… - Physics in Medicine …, 2023 - iopscience.iop.org
Focused ultrasound (FUS) is a non-invasive and highly promising method for targeted and
reversible blood-brain barrier permeabilization. Numerous preclinical studies aim to …
reversible blood-brain barrier permeabilization. Numerous preclinical studies aim to …
Blood–brain barrier opening in a large animal model using closed-loop microbubble cavitation-based feedback control of focused ultrasound sonication
Focused ultrasound (FUS) in combination with microbubbles has been established as a
promising technique for noninvasive and localized Blood–brain barrier (BBB) opening. Real …
promising technique for noninvasive and localized Blood–brain barrier (BBB) opening. Real …
Advancements in ultrasound-mediated drug delivery for central nervous system disorders
Introduction Central nervous system (CNS) disorders present major therapeutic challenges
due to the presence of the blood–brain barrier (BBB) and disease heterogeneity. The BBB …
due to the presence of the blood–brain barrier (BBB) and disease heterogeneity. The BBB …
Focused ultrasound–mediated liquid biopsy in a tauopathy mouse model
Background Neurodegenerative disorders (such as Alzheimer disease) characterized by the
deposition of various pathogenic forms of tau protein in the brain are collectively referred to …
deposition of various pathogenic forms of tau protein in the brain are collectively referred to …
Characterization of the targeting accuracy of a neuronavigation-guided transcranial FUS system in vitro, in vivo, and in silico
Focused ultrasound (FUS)-enabled liquid biopsy (sonobiopsy) is an emerging technique for
the noninvasive and spatiotemporally controlled diagnosis of brain cancer by inducing blood …
the noninvasive and spatiotemporally controlled diagnosis of brain cancer by inducing blood …
Small volume blood-brain barrier opening in macaques with a 1 MHz ultrasound phased array
The use of focused ultrasound to open the blood-brain barrier (BBB) has the potential to
deliver drugs to specific regions of the brain. The size of the BBB opening and ability to …
deliver drugs to specific regions of the brain. The size of the BBB opening and ability to …
Image-guided focused ultrasound-mediated molecular delivery to breast cancer in an animal model
Tumors become inoperable due to their size or location, making neoadjuvant chemotherapy
the primary treatment. However, target tissue accumulation of anticancer agents is limited by …
the primary treatment. However, target tissue accumulation of anticancer agents is limited by …
CMUT for ultrafast passive cavitation detection during ultrasound-induced blood–brain barrier disruption: proof of concept study
C Cornu, L Jourdain, F Barcella, L Colin… - Physics in Medicine …, 2024 - iopscience.iop.org
Objective. Cavitation dose monitoring plays a key role in ultrasound drug delivery to the
brain. The use of capacitive micromachined ultrasonic transducer (CMUT) technology has a …
brain. The use of capacitive micromachined ultrasonic transducer (CMUT) technology has a …
First-in-human prospective trial of sonobiopsy in glioblastoma patients using neuronavigation-guided focused ultrasound
Sonobiopsy is an emerging technology that combines focused ultrasound (FUS) with
microbubbles to enrich circulating brain disease-specific biomarkers for noninvasive …
microbubbles to enrich circulating brain disease-specific biomarkers for noninvasive …
Multimodal evaluation of blood-brain barrier opening in mice in response to low-intensity ultrasound and a claudin-5 binder
L Chen, J Song, G Richter-Stretton, W Lee… - …, 2024 - pmc.ncbi.nlm.nih.gov
Background: The blood-brain barrier (BBB) is a major bottleneck in delivering therapeutics
to the brain. Treatment strategies to transiently open this barrier include focused ultrasound …
to the brain. Treatment strategies to transiently open this barrier include focused ultrasound …