CRISPR-based precision molecular diagnostics for disease detection and surveillance
A Kulkarni, S Tanga, A Karmakar, A Hota… - ACS Applied Bio …, 2023 - ACS Publications
Sensitive, rapid, and portable molecular diagnostics is the future of disease surveillance,
containment, and therapy. The recent SARS-CoV-2 pandemic has reminded us of the …
containment, and therapy. The recent SARS-CoV-2 pandemic has reminded us of the …
Biomedical relevance of novel anticancer peptides in the sensitive treatment of cancer
The global increase in cancer mortality and economic losses necessitates the cautious
quest for therapeutic agents with compensatory advantages over conventional therapies …
quest for therapeutic agents with compensatory advantages over conventional therapies …
De Novo Discovery of High-Affinity Peptide Binders for the SARS-CoV-2 Spike Protein
The β-coronavirus SARS-CoV-2 has caused a global pandemic. Affinity reagents targeting
the SARS-CoV-2 spike protein are of interest for the development of therapeutics and …
the SARS-CoV-2 spike protein are of interest for the development of therapeutics and …
Selection for constrained peptides that bind to a single target protein
Peptide secondary metabolites are common in nature and have diverse pharmacologically-
relevant functions, from antibiotics to cross-kingdom signaling. Here, we present a method to …
relevant functions, from antibiotics to cross-kingdom signaling. Here, we present a method to …
Computational analysis of spike protein of SARS-CoV-2 (Omicron variant) for development of peptide-based therapeutics and diagnostics
In the last few years, the worldwide population has suffered from the SARS-CoV-2
pandemic. The WHO dashboard indicated that around 504,079,039 people were infected …
pandemic. The WHO dashboard indicated that around 504,079,039 people were infected …
Antibacterial activity of rationally designed antimicrobial peptides
Many infectious diseases are still prevalent in the world's populations since no effective
treatments are available to eradicate them. The reasons may either be the antibiotic …
treatments are available to eradicate them. The reasons may either be the antibiotic …
PZQ therapy: how close are we in the development of effective alternative anti-schistosomal drugs?
Today schistosomiasis, caused mainly by the three major schistosome species (S. mansoni,
S. haematobium and S. japonicum), has for many decades and still continues to be on a …
S. haematobium and S. japonicum), has for many decades and still continues to be on a …
[HTML][HTML] In silico prediction of new antimicrobial peptides and proteins as druggable targets towards alternative anti-schistosomal therapy
Schistosomiasis is a debilitating disease caused by a parasitic flatworm found in freshwater.
With the exponential increase in prevalence, Praziquantel (PZQ) remains the only effective …
With the exponential increase in prevalence, Praziquantel (PZQ) remains the only effective …
[PDF][PDF] In silico identification and molecular validation of putative antimicrobial peptides for HIV therapy.
Objective: Despite the effort to reduce the rate of HIV infection, AIDS still remains the major
cause of death around the world, predominantly in Sub-Sahara Africa. Neither a cure, nor an …
cause of death around the world, predominantly in Sub-Sahara Africa. Neither a cure, nor an …
Structural and molecular docking analytical studies of the predicted ligand binding sites of cadherin-1 in cancer prognostics
Introduction Several studies have explored the design of antimicrobial peptides (AMPs) for
the development of therapeutic and diagnostic molecules for the treatment and identification …
the development of therapeutic and diagnostic molecules for the treatment and identification …