The physiological role of α‐synuclein and its relationship to Parkinson's Disease

D Sulzer, RH Edwards - Journal of neurochemistry, 2019 - Wiley Online Library
The protein α‐synuclein has a central role in the pathogenesis of Parkinson's disease (PD).
In this review, we discuss recent results concerning its primary function, which appears to be …

Progress in microfluidics‐based exosome separation and detection technologies for diagnostic applications

S Lin, Z Yu, D Chen, Z Wang, J Miao, Q Li, D Zhang… - Small, 2020 - Wiley Online Library
Exosomes are secreted by most cell types and circulate in body fluids. Recent studies have
revealed that exosomes play a significant role in intercellular communication and are closely …

A genetically encoded fluorescent sensor enables rapid and specific detection of dopamine in flies, fish, and mice

F Sun, J Zeng, M Jing, J Zhou, J Feng, SF Owen, Y Luo… - Cell, 2018 - cell.com
Dopamine (DA) is a central monoamine neurotransmitter involved in many physiological
and pathological processes. A longstanding yet largely unmet goal is to measure DA …

A genetically encoded fluorescent acetylcholine indicator for in vitro and in vivo studies

M Jing, P Zhang, G Wang, J Feng, L Mesik… - Nature …, 2018 - nature.com
The neurotransmitter acetylcholine (ACh) regulates a diverse array of physiological
processes throughout the body. Despite its importance, cholinergic transmission in the …

Single-particle spectroscopy for functional nanomaterials

J Zhou, AI Chizhik, S Chu, D Jin - Nature, 2020 - nature.com
Tremendous progress in nanotechnology has enabled advances in the use of luminescent
nanomaterials in imaging, sensing and photonic devices. This translational process relies …

Quantum dots in bioanalysis: a review of applications across various platforms for fluorescence spectroscopy and imaging

E Petryayeva, WR Algar, IL Medintz - Applied spectroscopy, 2013 - journals.sagepub.com
Semiconductor quantum dots (QDs) are brightly luminescent nanoparticles that have found
numerous applications in bioanalysis and bioimaging. In this review, we highlight recent …

The synaptic vesicle cycle revisited: new insights into the modes and mechanisms

NL Chanaday, MA Cousin, I Milosevic… - Journal of …, 2019 - Soc Neuroscience
Neurotransmission is sustained by endocytosis and refilling of synaptic vesicles (SVs)
locally within the presynapse. Until recently, a consensus formed that after exocytosis, SVs …

Designing multifunctional quantum dots for bioimaging, detection, and drug delivery

P Zrazhevskiy, M Sena, X Gao - Chemical Society Reviews, 2010 - pubs.rsc.org
The emerging field of bionanotechnology aims at revolutionizing biomedical research and
clinical practice via introduction of nanoparticle-based tools, expanding capabilities of …

Exocytosis and endocytosis: modes, functions, and coupling mechanisms

LG Wu, E Hamid, W Shin… - Annual review of …, 2014 - annualreviews.org
Vesicle exocytosis releases content to mediate many biological events, including synaptic
transmission essential for brain functions. Following exocytosis, endocytosis is initiated to …

[HTML][HTML] Optical and non‐optical methods for detection and characterization of microparticles and exosomes

E Van Der Pol, AG Hoekstra, A Sturk, C Otto… - Journal of Thrombosis …, 2010 - Elsevier
Microparticles and exosomes are cell‐derived microvesicles present in body fluids that play
a role in coagulation, inflammation, cellular homeostasis and survival, intercellular …