Calcium signaling and genetic rare diseases: An auditory perspective
EM Richard, T Maurice, B Delprat - Cell Calcium, 2023 - Elsevier
Deafness is a highly heterogeneous disorder which stems, for 50%, from genetic origins.
Sensory transduction relies mainly on sensory hair cells of the cochlea, in the inner ear …
Sensory transduction relies mainly on sensory hair cells of the cochlea, in the inner ear …
Oncomodulin regulates spontaneous calcium signalling and maturation of afferent innervation in cochlear outer hair cells
Cochlear outer hair cells (OHCs) are responsible for the exquisite frequency selectivity and
sensitivity of mammalian hearing. During development, the maturation of OHC afferent …
sensitivity of mammalian hearing. During development, the maturation of OHC afferent …
Calcium-Associated Proteins in Neuroregeneration
The dysregulation of intracellular calcium levels is a critical factor in neurodegeneration,
leading to the aberrant activation of calcium-dependent processes and, ultimately, cell …
leading to the aberrant activation of calcium-dependent processes and, ultimately, cell …
Absence of oncomodulin increases susceptibility to noise-induced outer hair cell death and alters mitochondrial morphology
KE Murtha, WD Sese, K Sleiman, J Halpage… - Frontiers in …, 2024 - frontiersin.org
Cochlear outer hair cells (OHCs) play a fundamental role in the hearing sensitivity and
frequency selectivity of mammalian hearing and are especially vulnerable to noise-induced …
frequency selectivity of mammalian hearing and are especially vulnerable to noise-induced …
[HTML][HTML] Two new mouse alleles of Ocm and Slc26a5
M Lachgar-Ruiz, NJ Ingham, E Martelletti, J Chen… - Hearing Research, 2024 - Elsevier
The genes Ocm (encoding oncomodulin) and Slc26a5 (encoding prestin) are expressed
strongly in outer hair cells and both are involved in deafness in mice. However, it is not clear …
strongly in outer hair cells and both are involved in deafness in mice. However, it is not clear …
KLHDC7B, a novel gene associated with age-related hearing loss in humans, is required for the maintenance of hearing in mice.
AM Kaufman, B Silver, RA Donnianni, C Aguilar, L Niu… - bioRxiv, 2024 - biorxiv.org
Background: Age-related hearing loss (ARHL) is the most common sensory loss in older
adults, but the underlying pathological mechanisms remain unclear. Recent genome wide …
adults, but the underlying pathological mechanisms remain unclear. Recent genome wide …
Lack of Oncomodulin Increases ATP-Dependent Calcium Signaling and Susceptibility to Noise in Adult Mice
Tight regulation of Ca2+ is crucial for the function of cochlear outer hair cells (OHCs).
Dysregulation of Ca2+ homeostasis in OHCs is associated with impaired hearing function …
Dysregulation of Ca2+ homeostasis in OHCs is associated with impaired hearing function …
[PDF][PDF] Calcium-Associated Proteins in Neuroregeneration. Biomolecules 2024, 14, 183
The dysregulation of intracellular calcium levels is a critical factor in neurodegeneration,
leading to the aberrant activation of calcium-dependent processes and, ultimately, cell …
leading to the aberrant activation of calcium-dependent processes and, ultimately, cell …
Early Sensory Deficits in Alzheimer's Disease: A Review of Potential Integrating Diagnostic Methods
Y Yang - Journal of Clinical and Translational Science - cambridge.org
Alzheimer's Disease (AD) is the most common cause of dementia globally, leading to
memory loss and cognitive decline. Accumulating studies have uncovered the correlation …
memory loss and cognitive decline. Accumulating studies have uncovered the correlation …
[引用][C] Dysfunction of Calcium Regulation Mediates Processes Involved in Age-Related Hearing Loss
J Charles - 2022