Voltage-gated calcium channels are required for many key functions in the body. In this
review, the different subtypes of voltage-gated calcium channels are described and their …

Paracetamol (acetaminophen) is the most commonly used over‐the‐counter (OTC) drug in
the world. Despite its popularity and use for many years, the safety of its application and its …

Acute and chronic pain complaints, although common, are generally poorly served by
existing therapies. This unmet clinical need reflects a failure to develop novel classes of …

Voltage-gated calcium channels are the primary mediators of depolarization-induced
calcium entry into neurons. There is great diversity of calcium channel subtypes due to …

The detection and processing of painful stimuli in afferent sensory neurons is critically
dependent on a wide range of different types of voltage-and ligand-gated ion channels …

Chronic pain is a severely debilitating condition that reflects a long-term sensitization of
signal transduction in the afferent pain pathway. Among the key players in this pathway are …

A proper dialogue between spermatozoa and the egg is essential for conception of a new
individual in sexually reproducing animals. Ca2+ is crucial in orchestrating this unique event …

Sexually reproducing animals require an orchestrated communication between
spermatozoa and the egg to generate a new individual. Capacitation, a maturational …

Tryptase is a protein expressed by mast cells and basophils. 1, 2 Mature, enzymatically
active tryptases are tetrameric serine proteases that are stored in mast cell secretory …

Here, it is shown that paclitaxel-induced neuropathy is associated with the development of
spontaneous activity (SA) and hyperexcitability in dorsal root ganglion (DRG) neurons that is …