Cardiovascular diseases (CVDs) constitute the prime cause of global mortality, with an
immense impact on patient quality of life and disability. Clinical evidence has revealed a …

Senescent cell accumulation has been observed in age-associated diseases including
cardiovascular diseases. Senescent cells lack proliferative capacity and secrete senescence …

The mechanism by which aging induces aortic aneurysm and dissection (AAD) remains
unclear. A total of 430 participants were recruited for the screening of differentially …

Cardiovascular diseases (CVD) are predominantly an aging disease. Important sex-specific
differences exist and the mechanism (s) by which this sex-by-age interaction influences CVD …

Diabetic patients are frequently affected by coronary microvascular dysfunction (CMD), a
condition consisting of a combination of altered vasomotion and long-term structural change …

Senescence is an inevitable biological process. Disturbances in glucose and lipid
metabolism are essential features of cellular senescence. Given the important roles of these …

Cellular senescence is characterized by the permanent arrest of cell proliferation and is a
response to endogenous and exogenous stress. The continuous accumulation of senescent …

Cellular senescence is characteristic of the development and progression of multiple age-
associated diseases. Accumulation of senescent cells in the heart contributes to various age …

Cardiovascular aging presents a formidable challenge, as the aging process can lead to
reduced cardiac function and heightened susceptibility to cardiovascular diseases …

The influence of chronic diseases on various facets of macrophage cellular senescence is
poorly understood. This study evaluated the impact of chronic hyperglycemia on the …