Treg cell therapy: How cell heterogeneity can make the difference

G Giganti, M Atif, Y Mohseni… - European Journal of …, 2021 - Wiley Online Library
Abstract CD4+ CD25highCD127low/− FOXP3+ T regulatory cells are responsible for
maintaining immune tolerance and controlling excessive immune responses. Treg cell use …

[HTML][HTML] Feed-forward regulation between cellular senescence and immunosuppression promotes the aging process and age-related diseases

A Salminen - Ageing research reviews, 2021 - Elsevier
Aging is a progressive degenerative process involving a chronic low-grade inflammation
and the accumulation of senescent cells. One major issue is to reveal the mechanisms …

[HTML][HTML] Regulatory T cells in COVID-19

H Wang, Z Wang, W Cao, Q Wu, Y Yuan… - Aging and …, 2021 - ncbi.nlm.nih.gov
The outbreak of coronavirus disease 2019 (COVID-19) is caused by the infection of severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which leads to the disruption of …

Metabolic requirements of NK cells during the acute response against retroviral infection

E Littwitz-Salomon, D Moreira, JN Frost, C Choi… - Nature …, 2021 - nature.com
Natural killer (NK) cells are important early responders against viral infections. Changes in
metabolism are crucial to fuel NK cell responses, and altered metabolism is linked to NK cell …

SARS‐CoV‐2‐mediated immune system activation and potential application in immunotherapy

Y Tan, F Tang - Medicinal research reviews, 2021 - Wiley Online Library
Although novel severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2)‐mediated
pulmonary inflammation has recently attracted great attention, its pathology and …

Revisiting regulatory T cells as modulators of innate immune response and inflammatory diseases

Q Ou, R Power, MD Griffin - Frontiers in Immunology, 2023 - frontiersin.org
Regulatory T cells (Treg) are known to be critical for the maintenance of immune
homeostasis by suppressing the activation of auto-or allo-reactive effector T cells through a …

The role of natural killer cells in the immune response in kidney transplantation

P Pontrelli, F Rascio, G Castellano… - Frontiers in …, 2020 - frontiersin.org
Natural killer cells (NK) represent a population of lymphocytes involved in innate immune
response. In addition to their role in anti-viral and anti-tumor defense, they also regulate …

[HTML][HTML] NK cells enhance CAR-T cell antitumor efficacy by enhancing immune/tumor cells cluster formation and improving CAR-T cell fitness

M Bachiller, L Perez-Amill, AM Battram… - … for immunotherapy of …, 2021 - ncbi.nlm.nih.gov
Background Chimeric antigen receptor (CAR)-T cell immunotherapy has modified the
concept of treatment in hematological malignancies. In comparison with pediatric patients …

Natural killer cells in chronic lymphocytic leukemia: functional impairment and therapeutic potential

M Yano, JC Byrd, N Muthusamy - Cancers, 2022 - mdpi.com
Simple Summary Natural killer (NK) cells are immune cells with potent anti-tumor and anti-
infection activity. The potential benefit of NK cell therapy against chronic lymphocytic …

Obesity is associated with attenuated tissue immunity in COVID-19

SA Guo, GS Bowyer, JR Ferdinand, M Maes… - American journal of …, 2023 - atsjournals.org
Rationale: Obesity affects 40% of US adults, is associated with a proinflammatory state, and
presents a significant risk factor for the development of severe coronavirus disease (COVID …