The Flavivirus genus is made up of viruses that are either mosquito-borne, tick-borne and
other viruses transmitted by unknown vectors. Flaviviruses present a significant threat to …

The family Flaviviridae is comprised of a diverse group of arthropod-borne viruses that are
the etiological agents of globally relevant diseases in humans. Among these, infection with …

Tick-borne encephalitis (TBE) is a potentially fatal disease common in much of Europe and
Asia. There is no specific therapy for the treatment of TBE patients. However, several efforts …

Venezuelan equine encephalitis virus (VEEV) remains a risk for epidemic emergence or use
as an aerosolized bioweapon. To develop possible countermeasures, we isolated VEEV …

Inhibition of the binding of enveloped viruses surface glycoproteins to host cell receptor (s) is
a major target of vaccines and constitutes an efficient strategy to block viral entry and …

The tick-borne encephalitis virus (TBEV) is the arboviral etiological agent of tick-borne
encephalitis (TBE), considered to be one of the most important tick-borne viral diseases in …

Antigen-antibody interactions are a fundamental subset of protein-protein interactions
responsible for the “survival of the fittest”. Determining the interacting interface of the …

Powassan virus (POWV) is an emerging tick borne flavivirus (TBFV) that causes severe
neuroinvasive disease. Currently, there are no approved treatments or vaccines to combat …

Powassan viruses (POWVs) are neurovirulent tick-borne flaviviruses emerging in the
northeastern United States, with a 2% prevalence in Long Island (LI) deer ticks (Ixodes …

Powassan virus (POWV) is a tick-borne pathogen for which humans are an incidental host.
POWV infection can be fatal or result in long-term neurological sequelae; however, there are …