Epilepsy affects~ 65 million people worldwide. First-line treatment options include> 20
antiseizure medications, but seizure control is not achieved in approximately one-third of …

S100 is a multigenic family of non-ubiquitous Ca2+-modulated proteins of the EF-hand type
expressed in vertebrates exclusively and implicated in intracellular and extracellular …

The role of glial inflammatory processes in Alzheimer's disease has been highlighted by
recent epidemiological work establishing head trauma as an important risk factor, and the …

A multigenic family of Ca2+-binding proteins of the EF-hand type known as S100 comprises
19 members that are differentially expressed in a large number of cell types. Members of this …

Zinc is an important trace element in biology. An important pool of zinc in the brain is the one
present in synaptic vesicles in a subgroup of glutamatergic neurons. In this form it can be …

A glia-mediated, inflammatory immune response is an important component of the
neuropathophysiology of Alzheimer's disease, of the midlife neurodegeneration of Down's …

Neurological disorders (ND) are the central nervous system (CNS) related complications
originated by enhanced oxidative stress, mitochondrial failure and overexpression of …

Down syndrome (DS) is the result of triplication of chromosome 21 (trisomy 21) and is the
prevailing cause of mental retardation. In addition to the mental deficiencies and physical …

Neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and
amyotrophic lateral sclerosis, comprise a family of disorders characterized by progressive …

Postoperative cognitive dysfunction (POCD), as one of the common postoperative
complications, mainly occurs after surgery and anesthesia, especially in the elderly. It refers …