The failure of T cells to eradicate tumour cells in the tumour microenvironment is mainly due
to the dysfunction of T cells. Senescent T cells, with defects in proliferation and effector …

Chimeric antigen receptor (CAR) T cell therapy has achieved remarkable success in
hematological malignancies but remains ineffective in solid tumors, due in part to CAR T cell …

Antigen-induced memory T cells undergo counterintuitive activation in an antigen-
independent manner, which is called bystander response. Although it is well documented …

Background Immunotherapies still fail to benefit colorectal cancer (CRC) patients. Relevant
functional assays aimed at studying these failures and the efficacy of cancer immunotherapy …

Chimeric antigen receptor (CAR) T cell therapy is effective in treating B cell malignancies,
but factors influencing the persistence of functional CAR+ T cells, such as product …

The contribution of γδ T cells to immune responses is associated with rapid secretion of
interferon-γ (IFN-γ). Here, we show a perinatal thymic wave of innate IFN-γ-producing γδ T …

Subsets of the human CD8+ T cell population express inhibitory NK cell receptors, such as
killer immunoglobulin-like receptors (KIRs) and NKG2A. In the present study, we examine …

Cytotoxic T cell differentiation is guided by epigenome adaptations, but how epigenetic
mechanisms control lymphocyte development has not been well defined. Here we show that …

The viral reservoir is the major hurdle in developing and establishing an HIV cure.
Understanding factors affecting the size and decay of this reservoir is crucial for the …

Cancer cells can evade immune recognition by losing major histocompatibility complex
(MHC) class I. Hence, MHC class I-negative cancers represent the most challenging cancers …