RNA repair: hiding in plain sight
S Shuman - Annual Review of Genetics, 2023 - annualreviews.org
Enzymes that phosphorylate, dephosphorylate, and ligate RNA 5′ and 3′ ends were
discovered more than half a century ago and were eventually shown to repair purposeful …
discovered more than half a century ago and were eventually shown to repair purposeful …
[HTML][HTML] Jumbo phages: a comparative genomic overview of core functions and adaptions for biological conflicts
Jumbo phages have attracted much attention by virtue of their extraordinary genome size
and unusual aspects of biology. By performing a comparative genomics analysis of 224 …
and unusual aspects of biology. By performing a comparative genomics analysis of 224 …
Eukaryotic tRNA splicing–one goal, two strategies, many players
JL Gerber, S Köhler, J Peschek - Biological Chemistry, 2022 - degruyter.com
Transfer RNAs (tRNAs) are transcribed as precursor molecules that undergo several
maturation steps before becoming functional for protein synthesis. One such processing …
maturation steps before becoming functional for protein synthesis. One such processing …
Functionally comparable but evolutionarily distinct nucleotide-targeting effectors help identify conserved paradigms across diverse immune systems
While nucleic acid-targeting effectors are known to be central to biological conflicts and anti-
selfish element immunity, recent findings have revealed immune effectors that target their …
selfish element immunity, recent findings have revealed immune effectors that target their …
Structural and mechanistic insights into activation of the human RNA ligase RTCB by Archease
JL Gerber, SI Morales Guzmán, L Worf… - Nature …, 2024 - nature.com
RNA ligases of the RTCB-type play an essential role in tRNA splicing, the unfolded protein
response and RNA repair. RTCB is the catalytic subunit of the pentameric human tRNA …
response and RNA repair. RTCB is the catalytic subunit of the pentameric human tRNA …
Identification, characterization, and structure of a tRNA splicing enzyme RNA 5′-OH kinase from the pathogenic fungi Mucorales
S Ghosh, G Wimberly-Gard, A Jacewicz, B Schwer… - RNA, 2024 - rnajournal.cshlp.org
Fungal Trl1 is an essential tRNA splicing enzyme composed of C-terminal cyclic
phosphodiesterase and central polynucleotide kinase end-healing domains that convert the …
phosphodiesterase and central polynucleotide kinase end-healing domains that convert the …
Characterization of tRNA splicing enzymes RNA ligase and tRNA 2′-phosphotransferase from the pathogenic fungi Mucorales
S Ghosh, S Dantuluri, A Jacewicz, AM Sanchez… - RNA, 2024 - rnajournal.cshlp.org
Fungal Trl1 is an essential trifunctional tRNA splicing enzyme that heals and seals tRNA
exons with 2′, 3′-cyclic-PO4 and 5′-OH ends. Trl1 is composed of C-terminal cyclic …
exons with 2′, 3′-cyclic-PO4 and 5′-OH ends. Trl1 is composed of C-terminal cyclic …