p27Kip1 signaling: Transcriptional and post-translational regulation

SST Hnit, C Xie, M Yao, J Holst, A Bensoussan… - The international journal …, 2015 - Elsevier
Abstract p27 Kip1 is an inhibitor of a broad spectrum of cyclin-dependent kinases (CDKs),
and the loss of a single p27 Kip1 allele is thereby sufficient to increase tumor incidence via …

Cell cycle proteins in epithelial cell differentiation: implications for breast cancer

CE Caldon, RL Sutherland, EA Musgrove - Cell cycle, 2010 - Taylor & Francis
Proliferation and differentiation are tightly coupled processes, so that a final cell cycle is
often linked to the initiation of cell differentiation. The flux in cell cycle proteins during this …

Coordination behavior of cocaine toward d-block metal ions: synthesis, spectral analysis, density functional theory (DFT) studies, and chemotherapeutic activity

AM Abdallah, NG Zaki, AM El Kerdawy… - Journal of Molecular …, 2023 - Elsevier
The exploration of novel bioactive metallopharmaceuticals for the treatment of diseases
such as microbial infections or cancer, with a focus on reducing side effects and drug …

EKLF/KLF1-regulated cell cycle exit is essential for erythroblast enucleation

MN Gnanapragasam, KE McGrath… - Blood, The Journal …, 2016 - ashpublications.org
The mechanisms regulating the sequential steps of terminal erythroid differentiation remain
largely undefined, yet are relevant to human anemias that are characterized by ineffective …

Wogonoside induces cell cycle arrest and differentiation by affecting expression and subcellular localization of PLSCR1 in AML cells

Y Chen, H Hui, H Yang, K Zhao, Y Qin… - Blood, The Journal …, 2013 - ashpublications.org
Wogonoside is the main flavonoid component derived from the root of Scutellaria
baicalensis Georgi. It is a popular Chinese herbal medicine with the potential to treat …

SKP2 oncogene is a direct MYC target gene and MYC down-regulates p27KIP1 through SKP2 in human leukemia cells

G Bretones, JC Acosta, JM Caraballo… - Journal of Biological …, 2011 - ASBMB
SKP2 is the ubiquitin ligase subunit that targets p27 KIP1 (p27) for degradation. SKP2 is
induced in the G 1-S transit of the cell cycle, is frequently overexpressed in human cancer …

p27Kip1 represses transcription by direct interaction with p130/E2F4 at the promoters of target genes

R Pippa, L Espinosa, G Gundem, R Garcia-Escudero… - Oncogene, 2012 - nature.com
The cyclin-cdk (cyclin-dependent kinase) inhibitor p27 Kip1 (p27) has a crucial negative role
on cell cycle progression. In addition to its classical role as a cyclin-cdk inhibitor, it also …

Targeting of CTCF to the nucleolus inhibits nucleolar transcription through a poly (ADP-ribosyl) ation-dependent mechanism

V Torrano, J Navascués, F Docquier… - Journal of cell …, 2006 - journals.biologists.com
Multiple functions have been reported for the transcription factor and candidate tumour
suppressor, CTCF. Among others, they include regulation of cell growth, differentiation and …

The exosome complex establishes a barricade to erythroid maturation

SC McIver, YA Kang, AW DeVilbiss… - Blood, The Journal …, 2014 - ashpublications.org
Complex genetic networks control hematopoietic stem cell differentiation into progenitors
that give rise to billions of erythrocytes daily. Previously, we described a role for the master …

From cell cycle to differentiation: an expanding role for cdk6

MJ Grossel, PW Hinds - Cell cycle, 2006 - Taylor & Francis
Over ten years ago, cdk6 was identified as a new member in a family of vertebrate cdc-2
related kinases. This novel kinase was found to partner with the D-type cyclins and to …