A comprehensive review of m6A/m6Am RNA methyltransferase structures
S Oerum, V Meynier, M Catala, C Tisné - Nucleic acids research, 2021 - academic.oup.com
Gene expression is regulated at many levels including co-or post-transcriptionally, where
chemical modifications are added to RNA on riboses and bases. Expression control via RNA …
chemical modifications are added to RNA on riboses and bases. Expression control via RNA …
Roles of METTL3 in cancer: mechanisms and therapeutic targeting
C Zeng, W Huang, Y Li, H Weng - Journal of hematology & oncology, 2020 - Springer
Abstract N 6-methyladenosine (m 6 A) is the most abundant mRNA modification and is
catalyzed by the methyltransferase complex, in which methyltransferase-like 3 (METTL3) is …
catalyzed by the methyltransferase complex, in which methyltransferase-like 3 (METTL3) is …
[HTML][HTML] Lactylation-driven METTL3-mediated RNA m6A modification promotes immunosuppression of tumor-infiltrating myeloid cells
J Xiong, J He, J Zhu, J Pan, W Liao, H Ye, H Wang… - Molecular cell, 2022 - cell.com
Tumor-infiltrating myeloid cells (TIMs) are crucial cell populations involved in tumor immune
escape, and their functions are regulated by multiple epigenetic mechanisms. The precise …
escape, and their functions are regulated by multiple epigenetic mechanisms. The precise …
Dynamic transcriptomic m6A decoration: writers, erasers, readers and functions in RNA metabolism
Abstract N 6-methyladenosine (m6A) is a chemical modification present in multiple RNA
species, being most abundant in mRNAs. Studies on enzymes or factors that catalyze …
species, being most abundant in mRNAs. Studies on enzymes or factors that catalyze …
Redox regulation of m6A methyltransferase METTL3 in β-cells controls the innate immune response in type 1 diabetes
Abstract Type 1 diabetes (T1D) is characterized by the destruction of pancreatic β-cells.
Several observations have renewed the interest in β-cell RNA sensors and editors. Here, we …
Several observations have renewed the interest in β-cell RNA sensors and editors. Here, we …
Cryo-EM structures of human m6A writer complexes
Abstract N 6-methyladenosine (m6A) is the most abundant ribonucleotide modification
among eukaryotic messenger RNAs. The m6A “writer” consists of the catalytic subunit m6A …
among eukaryotic messenger RNAs. The m6A “writer” consists of the catalytic subunit m6A …
Engineered LwaCas13a with enhanced collateral activity for nucleic acid detection
Clustered regularly interspaced short palindromic repeats (CRISPR)–CRISPR-associated
protein 13 (Cas13) has been rapidly developed for nucleic-acid-based diagnostics by using …
protein 13 (Cas13) has been rapidly developed for nucleic-acid-based diagnostics by using …
Alternative splicing of METTL3 explains apparently METTL3-independent m6A modifications in mRNA
N 6-methyladenosine (m6A) is a highly prevalent mRNA modification that promotes
degradation of transcripts encoding proteins that have roles in cell development …
degradation of transcripts encoding proteins that have roles in cell development …
RNA methyltransferase METTL16: Targets and function
ER Satterwhite, KD Mansfield - Wiley Interdisciplinary Reviews …, 2022 - Wiley Online Library
Abstract The N6‐methyladenosine (m6A) RNA methyltransferase METTL16 is an emerging
player in the RNA modification landscape of the human cell. Originally thought to be a …
player in the RNA modification landscape of the human cell. Originally thought to be a …
The m6A Writer: Rise of a Machine for Growing Tasks
DL Balacco, M Soller - Biochemistry, 2018 - ACS Publications
The central dogma of molecular biology introduced by Crick describes a linear flow of
information from DNA to mRNA to protein. Since then it has become evident that RNA …
information from DNA to mRNA to protein. Since then it has become evident that RNA …