Janus tyrosine kinase (JAK) family of proteins have been identified as crucial proteins in
signal transduction initiated by a wide range of membrane receptors. Among the proteins in …

In recent years, a lot of scientific interest has focused on cancer immunotherapy. Although
chronic inflammation has been described as one of the hallmarks of cancer, acute …

Cancer stem cells (CSCs) are critical for cancer progression and chemoresistance. How
lipid metabolism regulates CSCs and chemoresistance remains elusive. Here, we …

Although obesity is known to be critical for cancer development, how obesity negatively
impacts antitumor immune responses remains largely unknown. Here, we show that …

Abstract The Janus kinases (JAKs) and signal transducer and activator of transcription
(STAT) proteins, particularly STAT3, are among the most promising new targets for cancer …

Toll-like receptors (TLRs) serve as the body's first line of defense, recognizing both
pathogen-expressed molecules and host-derived molecules released from damaged or …

Over the last decades, the cancer survival rate has increased due to personalized therapies,
the discovery of targeted therapeutics and novel biological agents, and the application of …

Combination therapy is increasingly becoming the cornerstone of current day antitumor
therapy. Glioblastoma multiforme is an aggressive brain tumor with a dismal median survival …

Signal transducer and activator of transcription 3 (STAT3) is one of the crucial transcription
factors, responsible for regulating cellular proliferation, cellular differentiation, migration …

STAT3 is both a transcription activator and an oncogene that is tightly regulated under
normal physiological conditions. However, abundant evidence indicates that STAT3 is …