Placenta-on-a-Chip as an In Vitro Approach to Evaluate the Physiological and Structural Characteristics of the Human Placental Barrier upon Drug Exposure: A …

FA Elzinga, B Khalili, DJ Touw, JR Prins… - Journal of Clinical …, 2023 - mdpi.com
Quantification of fetal drug exposure remains challenging since sampling from the placenta
or fetus during pregnancy is too invasive. Currently existing in vivo (eg, cord blood sampling) …

Surface Deformation of Biocompatible Materials: Recent Advances in Biological Applications

S Yoon, A Fuwad, S Jeong, H Cho, TJ Jeon, SM Kim - Biomimetics, 2024 - mdpi.com
The surface topography of substrates is a crucial factor that determines the interaction with
biological materials in bioengineering research. Therefore, it is important to appropriately …

Microfluidic outer blood–retinal barrier model for inducing wet age-related macular degeneration by hypoxic stress

S Lee, S Kim, JS Jeon - Lab on a Chip, 2022 - pubs.rsc.org
Wet age-related macular degeneration (AMD) is a severe ophthalmic disease that develops
in the outer blood–retinal barrier (oBRB), involving two types of cells, the retinal pigment …

Endocrine-disrupting compounds and their impact on human placental function: evidence from placenta organ-on-chip studies

MS Vidal, LS Richardson, AK Kammala, S Kim… - Lab on a Chip, 2024 - pubs.rsc.org
The effects of endocrine-disrupting compounds (EDCs) on the placenta, a critical gestational
organ for xenobiotic protection, are well reported; however, models to determine the role of …

[HTML][HTML] Development of albumin monitoring system with hepatic hypoxia-on-a-chip

JY Kim, Y Han, BG Jeon, MS Nam, S Kwon, YJ Heo… - Talanta, 2023 - Elsevier
Hypoxia plays an essential role in the pathogenesis of various liver diseases, and albumin is
one of the important biomarkers secreted by the liver. In this study, we developed an …

Modeling Preeclampsia: From 2D Cultures to Placenta-on-a-Chip Technologies

E Knyazev, P Vishnyakova, O Lazareva, A Tonevitsky - BioChip Journal, 2025 - Springer
Preeclampsia is a complex pregnancy disorder marked by hypertension and proteinuria,
often resulting in significant maternal and fetal morbidity and mortality. Understanding its …

A Microphysiological Model to Mimic the Placental Remodeling during Early Stage of Pregnancy under Hypoxia-Induced Trophoblast Invasion

S Jeong, A Fuwad, S Yoon, TJ Jeon, SM Kim - Biomimetics, 2024 - mdpi.com
Placental trophoblast invasion is critical for establishing the maternal–fetal interface, yet the
mechanisms driving trophoblast-induced maternal arterial remodeling remain elusive. To …

Reproductive organ on-a-chip technologies and assessments of the fetal-maternal interface

HA Richards, AJ Eastman, DR Miller… - Frontiers in Lab on a …, 2024 - frontiersin.org
In this review, we discuss recent reproductive organ-on-a-chip (OoC) experiments that
encompass multiple target areas of investigation, including model fabrication strategies …

Fabrication of a cell-friendly poly (dimethylsiloxane) culture surface via polydopamine coating

DH Yang, S Jung, JY Kim, NY Lee - Micromachines, 2022 - mdpi.com
In this study, we fabricated a poly (dimethylsiloxane)(PDMS) surface coated with
polydopamine (PDA) to enhance cell adhesion. PDA is well known for improving surface …