Porous nanoparticle-supported lipid bilayers (protocells) for targeted delivery and methods of using same

CJ Brinker, EC Carnes, CE Ashley… - US Patent …, 2017 - Google Patents
The present invention is directed to protocells for specific targeting of hepatocellular and
other cancer cells which comprise a nanoporous silica core with a supported lipid bilayer; at …

Method for increasing the permeability of an epithelial barrier

RF Ross - US Patent 9,586,044, 2017 - Google Patents
3,797.494. A 3, 1974 Zaffaroni 3,964,482 A 6, 1976 Gerstel et al. 4,031,894 A 6/1977
Urquhart et al. 4,051,840 A 10, 1977 Kantrowitz et al. 4,201,211 A 5/1980 Chandrasekaran …

Antimicrobial mesoporous silica nanoparticles

V Lin, B Trewyn, S Huh, C Whitman - US Patent App. 10/945,545, 2006 - Google Patents
Methods for preparing a series of rnesoporous silicates, such as room-temperature ionic
liquid (RTIL)-templated meso porous silicate particles, With various particle morphologies …

Mesoporous silica nanoparticles for biomedical applications

M Liong, J Lu, F Tamanoi, JI Zink, A Nel - US Patent 9,993,437, 2018 - Google Patents
(57) ABSTRACT A submicron structure includes a silica body defining a plurality of pores
that are suitable to receive molecules therein, the silica body further defining an outer …

Nanopatterned medical device with enhanced cellular interaction

RF Ross - US Patent 10,245,421, 2019 - Google Patents
Disclosed are nanotopography-based methods and devices for interacting with a
component of the dermal connective tissue. Devices include structures fabricated on a …

Device for delivery of rheumatoid arthritis medication

RF Ross - US Patent 9,522,263, 2016 - Google Patents
Disclosed are devices for delivering a rheumatoid arthritis drug across a dermal barrier. The
devices include microneedles for penetrating the stratum corneum and also include …

Cationic polymer coated mesoporous silica nanoparticles and uses thereof

JI Zink, AE Nel, T Xia, Z Ji, H Meng, Z Li… - US Patent App. 13 …, 2012 - Google Patents
2012-05-15 Assigned to NATIONAL INSTITUTES OF HEALTH (NIH), US DEPT. OF HEALTH
AND HUMAN SERVICES (DHHS), US GOVERNMENT reassignment NATIONAL …

Porous nanoparticle supported lipid bilayer nanostructures

J Liu, JC Brinker, C Ashley, EC Carnes - US Patent 8,734,816, 2014 - Google Patents
Various exemplary embodiments provide protocell nanostructures and methods for
constructing and using the protocell nanostructures. In one embodiment, the protocell …

Composite microneedle array including nanostructures thereon

RF Ross - US Patent 9,526,883, 2016 - Google Patents
Disclosed are composite microneedles arrays including microneedles and a film overlaying
the microneedles. The film includes a plurality of nano-sized structures fabricated thereon …

Composition containing loaded and capped porous silica particles

L Canham, QUA Shabir, A Loni - US Patent 9,243,144, 2016 - Google Patents
(57) ABSTRACT A consumer care composition or a food composition com prising a
mesoporous microparticulate material wherein at least some of the pores of the material are …