Stress proteins: the biological functions in virus infection, present and challenges for target-based antiviral drug development

Q Wan, D Song, H Li, M He - Signal transduction and targeted therapy, 2020 - nature.com
Stress proteins (SPs) including heat-shock proteins (HSPs), RNA chaperones, and ER
associated stress proteins are molecular chaperones essential for cellular homeostasis. The …

Heat shock proteins in Alzheimer's disease: role and targeting

C Campanella, A Pace, C Caruso Bavisotto… - International journal of …, 2018 - mdpi.com
Among diseases whose cure is still far from being discovered, Alzheimer's disease (AD) has
been recognized as a crucial medical and social problem. A major issue in AD research is …

Aiming for the ideal synthesis

T Gaich, PS Baran - The Journal of organic chemistry, 2010 - ACS Publications
The field of total synthesis has a rich history and a vibrant future. Landmark advances and
revolutionary strides in the logic of synthesis have put the practicing chemist in the enviable …

Synthesis at the molecular frontier

PA Wender, BL Miller - Nature, 2009 - nature.com
Synthesis at the molecular frontier | Nature Skip to main content Thank you for visiting nature.com.
You are using a browser version with limited support for CSS. To obtain the best experience …

Electrophilic natural products and their biological targets

M Gersch, J Kreuzer, SA Sieber - Natural product reports, 2012 - pubs.rsc.org
Covering: 1900 to 2011 The study of biologically active natural products has resulted in
seminal contributions to our understanding of living systems. In the case of electrophilic …

Natural products from mangrove sediments-derived microbes: Structural diversity, bioactivities, biosynthesis, and total synthesis

K Li, S Chen, X Pang, J Cai, X Zhang, Y Liu… - European Journal of …, 2022 - Elsevier
The mangrove forests are a complex ecosystem, and the microbial communities in
mangrove sediments play a critical role in the biogeochemical cycles of mangrove …

Structural diversity and biological activities of indole diketopiperazine alkaloids from fungi

YM Ma, XA Liang, Y Kong, B Jia - Journal of agricultural and food …, 2016 - ACS Publications
Indole diketopiperazine alkaloids are secondary metabolites of microorganisms that are
widely distributed in filamentous fungi, especially in the genera Aspergillus and Penicillium …

Capturing biological activity in natural product fragments by chemical synthesis

EA Crane, K Gademann - Angewandte Chemie International …, 2016 - Wiley Online Library
Natural products have had an immense influence on science and have directly led to the
introduction of many drugs. Organic chemistry, and its unique ability to tailor natural products …

Toward developing chemical modulators of Hsp60 as potential therapeutics

Q Meng, BX Li, X Xiao - Frontiers in molecular biosciences, 2018 - frontiersin.org
The 60 kDa heat shock protein (Hsp60) is classically known as a mitochondrial chaperonin
protein working together with co-chaperonin 10 kDa heat shock protein (Hsp10). This …

Hsp60 chaperonopathies and chaperonotherapy: targets and agents

F Cappello, A Marino Gammazza… - Expert opinion on …, 2014 - Taylor & Francis
Introduction: Hsp60 (Cpn60) assembles into a tetradecamer that interacts with the co-
chaperonin Hsp10 (Cpn10) to assist client polypeptides to fold, but it also has other roles …