Human beings are adept at discerning relevant information from complex systems by
processing visual information. Similarly, as scientists labor to understand the fundamental …

The primary function of the eye lens is to focus light on the retina. The major proteins in the
lens—α, β, and γ-crystallins—are constantly subjected to age-related changes such as …

Matrix-assisted laser desorption/ionization (MALDI) imaging mass spectrometry (IMS) is a
powerful tool for investigating the distribution of proteins and small molecules within …

Spatial proteomics has the potential to significantly advance our understanding of biology,
physiology and medicine. Matrix-assisted laser desorption/ionisation mass spectrometry …

The refractive power of a lens is determined largely by its surface curvatures and the
refractive index of its medium. These properties can also be used to control the sharpness of …

purpose. To develop a protocol for MALDI (matrix-assisted laser desorption ionization)
imaging mass spectrometry for mapping the distributions of α-crystallin and its modified …

Matrix-assisted laser desorption ionization-mass spectrometry (MALDI-MS) imaging is a
powerful technique giving access to the distribution of a large range of biomolecules directly …

γ-Crystallins constitute the major protein component in the nucleus of the vertebrate eye
lens. Present at very high concentrations, they exhibit extreme solubility and thermodynamic …

This review describes the current state of mass spectrometry imaging (MSI) in life sciences.
A brief overview of mass spectrometry principles is presented followed by a thorough …

Lens crystallin proteins make up 90% of expressed proteins in the ocular lens and are
primarily responsible for maintaining lens transparency and establishing the gradient of …