Second harmonic generation (SHG) and third harmonic generation (THG) microscopies
have emerged as powerful imaging modalities to examine structural properties of a wide …

Mesenchymal stem cell (MSC) chondrogenesis in three-dimensional (3D) culture involves
dynamic changes in cytoskeleton architecture during mesenchymal condensation before …

Pathogenesis of many diseases is associated with changes in the collagen spatial structure.
Traditionally, the 3D structure of collagen in biological tissues is analyzed using …

Osteoarthritis (OA) is characterized by the progressive deterioration of articular cartilage,
involving complicated cell-matrix interactions. Systematic investigations of dynamic cellular …

Idiopathic pulmonary fibrosis (IPF) is a complex disease of unknown etiology with no current
curative treatment. Modeling pulmonary fibrotic (PF) tissue has the potential to improve our …

Traumatic brain injury (TBI) survivors suffer long term from mental illness,
neurodegeneration, and neuroinflammation. Studies of 3D tissue models have provided …

Despite careful staging, the accuracy for preoperative detection of small distant metastases
remains poor, creating a clinical need for enhanced operative staging to detect occult …

Port wine stain (PWS) is a congenital cutaneous capillary malformation composed of ecstatic
vessels, while the microstructure of these vessels remains largely unknown. Optical …

Cerebrovascular disease includes all disorders that affect cerebrovascular and cerebral
circulation. Unfortunately, there is currently a lack of a systematic method to image blood …

Skin is a heterogeneous tissue that can undergo substantial structural and functional
changes with age, disease, or following injury. Understanding how these changes impact …