Emerging concepts in dendrimer‐based nanomedicine: from design principles to clinical applications

RM Kannan, E Nance, S Kannan… - Journal of internal …, 2014 - Wiley Online Library
Dendrimers are discrete nanostructures/nanoparticles with 'onion skin‐like'branched layers.
Beginning with a core, these nanostructures grow in concentric layers to produce stepwise …

[HTML][HTML] Micro-and nanotechnology in biomedical engineering for cartilage tissue regeneration in osteoarthritis

Z Nabizadeh, M Nasrollahzadeh… - Beilstein Journal of …, 2022 - beilstein-journals.org
Osteoarthritis, which typically arises from aging, traumatic injury, or obesity, is the most
common form of arthritis, which usually leads to malfunction of the joints and requires …

Critical adhesion areas of cells on micro-nanopatterns

S Zheng, Q Liu, J He, X Wang, K Ye, X Wang, C Yan… - Nano Research, 2022 - Springer
Cell adhesion to extracellular matrices (ECM) is critical to physiological and pathological
processes as well as biomedical and biotechnological applications. It has been known that a …

Fluorescent silicon nanoparticles-based nanotheranostic agents for rapid diagnosis and treatment of bacteria-induced keratitis

L Zhang, X Ji, Y Su, X Zhai, H Xu, B Song, A Jiang… - Nano Research, 2021 - Springer
Recommended as a medical emergency, infectious keratitis with an acute and rapid disease
progression can lead to serious damage of vision and even blindness. Herein, we present a …

Ligand density-dependent influence of arginine–glycine–aspartate functionalized gold nanoparticles on osteogenic and adipogenic differentiation of mesenchymal …

J Li, Y Chen, N Kawazoe, G Chen - Nano Research, 2018 - Springer
Extracellular matrix (ECM) plays a very important role in regulating cell function and fate. It is
highly desirable to fabricate biomimetic models to investigate the role of ECM in stem cell …

Hierarchical Quatsome-RGD Nanoarchitectonic Surfaces for Enhanced Integrin-Mediated Cell Adhesion

M Martínez-Miguel, M Castellote-Borrell… - … applied materials & …, 2022 - ACS Publications
The synthesis and study of the tripeptide Arg-Gly-Asp (RGD), the binding site of different
extracellular matrix proteins, eg, fibronectin and vitronectin, has allowed the production of a …

Substrate adhesion determines migration during mesenchymal cell condensation in chondrogenesis

I Casanellas, H Jiang, CM David, Y Vida… - Journal of Cell …, 2022 - journals.biologists.com
Mesenchymal condensation is a prevalent morphogenetic transition that is essential in
chondrogenesis. However, the current understanding of condensation mechanisms is …

Block copolymer nanopatterns affect cell spreading: Stem versus cancer bone cells

R Fontelo, DS da Costa, RL Reis… - Colloids and Surfaces B …, 2022 - Elsevier
Bone healing after a tumor removal can be promoted by biomaterials that enhance the bone
regeneration and prevent the tumor relapse. Herein, we obtained several nanopatterns by …

Recent advances in engineering nanotopographic substrates for cell studies

I Casanellas, J Samitier, A Lagunas - Frontiers in Bioengineering and …, 2022 - frontiersin.org
Cells sense their environment through the cell membrane receptors. Interaction with
extracellular ligands induces receptor clustering at the nanoscale, assembly of the signaling …

Tailoring RGD local surface density at the nanoscale toward adult stem cell chondrogenic commitment

A Lagunas, I Tsintzou, Y Vida, D Collado… - Nano Research, 2017 - Springer
Arginine-glycine-aspartic acid (RGD) dendrimer-based nanopatterns on poly (L-lactic acid)
were used as bioactive substrates to evaluate the impact of the RGD local surface density on …