Recent years have seen the creation and popularization of various complex in vitro models
(CIVMs), such as organoids and organs-on-chip, as a technology with the potential to …

Diseases leading to retinal cell loss can cause severe visual impairment and blindness. The
lack of effective therapies to address retinal cell loss and the absence of intrinsic …

Abstract Bisphenols, including Bisphenol A (BPA), Tetrabromobisphenol A (TBBPA), and
Tetrabromobisphenol S (TBBPS), have been widely applied in the production of …

Human-induced pluripotent stem cells (hiPSCs) have provided new methods to study
neurodegenerative diseases. In addition to their wide application in neuronal disorders …

Blindness poses a growing global challenge, with approximately 26% of cases attributed to
degenerative retinal diseases. While gene therapy, optogenetic tools, photosensitive …

Molecular information on the early stages of human retinal development remains scarce due
to limitations in obtaining early human eye samples. Pluripotent stem cell-derived retinal …

Hypoxia‐inducible factor (HIF) plays a critical role in the mechanisms that allow cells to
adapt to various oxygen levels in the environment. Specifically, HIF‐1⍺ has shown to be …

While exaptation is most impressive when links between very dissimilar contexts are
established, it can be even more pervasive when the previously unestablished connection …

Parkinson's disease (PD) is a neurodegenerative disorder marked by the loss of
dopaminergic neurons in the substantia nigra. Despite progress, the pathogenesis remains …

Recent development of human three-dimensional organoid cultures has opened new doors
and opportunities ranging from modelling human development in vitro to personalised …