Accurate in vivo predictions of intestinal absorption of low solubility drugs require knowing
their solubility in physiologically relevant dissolution media. Aspirated human intestinal …

Mucoadhesive microspheres have their own significant amongst the various sustained
release drug delivery systems. The prolonged residence time of these delivery devices at …

The purpose of the present study was to prepare Orodispersible films (ODFs) loaded with
ketoprofen nanoparticles (KT-NP). The Box-Behnken design was constructed in developing …

A model was previously derived to predict in vitro dissolution of drug into surfactant solution
and showed good predictability for pharmaceutical surfactants, where surfactant-mediated …

A previously developed model showed good predictability for in vitro drug dissolution into
FeSSGF and FeSSIF-V2, where biorelevant media-mediated enhanced drug dissolution by …

In vitro dissolution generally involves sink conditions, so dissolution equations generally do
not need to accommodate non-sink conditions. Greater use of biorelevant media, which are …

A dissolution-permeation system has potential to provide insight into the kinetic contributions
of dissolution and permeation to overall drug absorption. The goals of the study were to …

The influence mechanism of biorelevant media on the dissolution of active pharmaceutical
ingredients (APIs) is the key to their formulation design. The dissolution kinetics of naproxen …

Ketoconazole has low solubility in intestinal pH, whereas drug absorption is largest in the
small intestine, which can reduce the bioavailability of the drug. Alginate can be combined …

This special issue of Pharmaceutical Research is dedicated to Professor Kenneth R. Morris,
who for more than 3 decades has been a leader in research devoted to the interplay …