Essentially all cells contain a variety of spatially restricted regions that are important for
carrying out specialized functions. Often, these regions contain specialized transcriptomes …

Patterns of transcriptional activity are encoded in our genome through regulatory elements
such as promoters or enhancers that, paradoxically, contain similar assortments of …

Patients diagnosed with coronavirus disease 2019 (COVID-19) become critically ill primarily
around the time of activation of the adaptive immune response. Here, we provide evidence …

Type I and II interferons (IFNs) stimulate pro-inflammatory programs that are critical for
immune activation, but also induce immune-suppressive feedback circuits that impede …

Advances in RNA-sequencing technologies have led to the development of intriguing
experimental setups, a massive accumulation of data, and high demand for tools to analyze …

Impaired cerebral glucose metabolism is a pathologic feature of Alzheimer's disease (AD),
with recent proteomic studies highlighting disrupted glial metabolism in AD. We report that …

CRISPR/Cas9 gene editing can inactivate genes in a precise manner. This process involves
DNA double-strand breaks (DSB), which may incur a loss of cell fitness. We hypothesize that …

Abstracts Early B cell lymphopoiesis depends on E2A, Ebf1, Pax5 and Ikaros family
members. In the present study, we used acute protein degradation in mice to identify direct …

During wound healing, different pools of stem cells (SCs) contribute to skin repair. However,
how SCs become activated and drive the tissue remodeling essential for skin repair is still …

Summary RNA polymerase II (RNA Pol II) is generally paused at promoter-proximal regions
in most metazoans, and based on in vitro studies, this function has been attributed to the …