Hyaluronan (HA) is a linear nonsulfated glycosaminoglycan of the extracellular matrix that
plays a pivotal role in a variety of biological processes. High‐molecular weight HA exhibits …

The epidermal growth factor receptor (EGFR) belongs to the tyrosine kinase receptors family
and is present in the epithelial cell membrane. Its endogenous activation occurs through the …

Despite significant improvements of new treatment options, cancer continues to represent as
one of the most common and fatal disease. The EGFR signaling pathway is considered as a …

The current research employed an animal model of 7, 12-dimethylbenz (a) anthracene
(DMBA)-induced mammary gland carcinogenesis. The estrogen receptor-positive human …

Drug delivery is a fascinating research field with several development opportunities. Great
attention is now focused on colloidal systems, nanoparticles, and nanogels and on the …

Epidermal growth factor receptor (EGFR), also known as ErbB-1/HER-1, plays a key role in
the regulation of the cell proliferation, migration, differentiation, and survival. Since the …

Extracellular matrixes (ECMs) are intricate 3-dimensional macromolecular networks of
unique architectures with regulatory roles in cell morphology and functionality. As a dynamic …

In recent years, nanogels have emerged as promising drug delivery vehicles; their ability in
holding active molecules, macromolecules and drugs, together with the capability to …

Abstract Series of piperidone-salicylate conjugates were synthesized through the reaction of
3E, 5E-bis (arylidene)-4-piperidones with the appropriate acid chloride of acetylsalicylate in …

Cancer cell invasion into the surrounding extracellular matrix (ECM) takes place when cell-
cell junctions are disrupted upon epithelial-to-mesenchymal transition (EMT). Both cancer …