Osteoarthritis (OA) is the most common form of arthritis. It is characterized by progressive
destruction of articular cartilage and the development of chronic pain and constitutes a …

The clinical and commercial success of covalent drugs has prompted a renewed and more
deliberate pursuit of covalent and irreversible mechanisms within drug discovery. A covalent …

The two main strategies for enzyme engineering, directed evolution and rational design,
have found widespread applications in improving the intrinsic activities of proteins. Although …

The microenvironment is known to critically modulate tumor progression, yet its role in
regulating treatment response is poorly understood. Here we found increased macrophage …

Proteases or proteolytic enzymes form one of the largest and more important groups of
enzymes. Proteases selectively catalyze the hydrolysis of peptide bonds and can be divided …

Sterile particles induce robust inflammatory responses that underlie the pathogenesis of
diseases like silicosis, gout, and atherosclerosis. A key cytokine mediating this response is …

Lysosomes are the key degradative compartments of the cell. Lysosomal cathepsins, which
are enclosed in the lysosomes, help to maintain the homeostasis of the cell's metabolism by …

Proteasome inhibitors are used to treat blood cancers such as multiple myeloma (MM) and
mantle cell lymphoma. The efficacy of these drugs is frequently undermined by acquired …

Tumors develop through successive stages characterized by changes in gene expression
and protein function. Gene expression profiling of pancreatic islet tumors in a mouse model …

Der" Sewald/Jakubke" ist und bleibt das einzige moderne, auf dem neuesten
wissenschaftlichen Stand gehaltene fortgeschrittene Lehrbuch der Peptid-Biochemie! Auch …