The discovery over two decades ago of short regulatory microRNAs (miRNAs) has led to the
inception of a vast biomedical research field dedicated to understanding these powerful …

Nutrigenomics explains the interaction between the genome, the proteome, the epigenome,
the metabolome, and the microbiome with the nutritional environment of an organism. It is …

The adipose tissue plays a crucial role in metabolism and physiology, affecting animal
lifespan and susceptibility to disease. In this study, we present evidence that adipose Dicer1 …

While neurotransmitter identity was once considered singular and immutable for mature
neurons, it is now appreciated that one neuron can release multiple neuroactive substances …

Many biological and behavioural processes of animals are governed by an endogenous
circadian clock, which is dependent on transcriptional regulation. Here we address post …

Adult organisms must sense and adapt to environmental fluctuations. In high-turnover
tissues such as the intestine, these adaptive responses require rapid changes in gene …

Circadian rhythms in metazoan eukaryotes are controlled by an endogenous molecular
clock. It functions in many locations, including subsets of brain neurons (clock neurons) …

Short regulatory RNA molecules underpin gene expression and govern cellular state and
physiology. To establish an alternative layer of control over these processes, we generated …

To discover microRNAs that regulate sleep, we performed a genetic screen using a library of
miRNA sponge-expressing flies. We identified 25 miRNAs that regulate baseline sleep; 17 …

The Drosophila melanogaster corpus allatum (CA) produces and releases three types of
sesquiterpenoid hormones, including juvenile hormone III bisepoxide (JHB3), juvenile …