Inactivation of p53 is critical for the formation of most tumors. Illumination of the key function
(s) of p53 protein in protecting cells from becoming cancerous is therefore a worthy goal …

BRCA1 (BReast‐CAncer susceptibility gene 1) and BRCA2 are tumor suppressor genes, the
mutant phenotypes of which predispose to breast and ovarian cancers. Intensive research …

Breast cancer is a global burden with a woman's lifetime risk of developing breast cancer at
1 in 8. Although breast cancer is a disease that affects mostly women, the lifetime risk in men …

Publisher Summary The p53 protein is a tight, hydrophobic central globule containing the
DNA binding domain, flanked by accessible N-and C-terminal regions. This protein is …

Abnormalities of the p53 tumour suppressor gene are among the most frequent molecular
events in human and animal neoplasia. Moreover, p53 is one of the most studied proteins in …

Regulation, recognition and cell signaling involve the coordinated actions of many players.
To achieve this coordination, each participant must have a valid identification (ID) that is …

Germline mutations in the tumor suppressor genes BRCA1 and BRCA2 predispose
individuals to breast and ovarian cancers. Progress in determining the function of BRCA1 …

The BRCA1 and BRCA2 proteins are important in maintaining genomic stability by
promoting efficient and precise repair of double-strand breaks. The main role of BRCA2 …

A number of proteins are activated by stress stimuli but none so spectacularly or with the
degree of complexity as the tumour suppressor p53 (human p53 gene or protein). Once …

Abstract p53 mutation remains the most common genetic change identified in human
neoplasia. In breast cancer, p53 mutation is associated with more aggressive disease and …