Metabolic reprogramming is one of the hallmarks of cancer. As nutrients are scarce in the
tumor microenvironment (TME), tumor cells adopt multiple metabolic adaptations to meet …

Pancreatic cancer, specifically pancreatic ductal adenocarcinoma (PDAC), presents a
challenging landscape due to its complex nature and the highly immunosuppressive tumor …

Small cell lung cancer (SCLC) is a recalcitrant, relatively immune-cold, and deadly subtype
of lung cancer. SCLC has been viewed as a single or homogenous disease that includes …

The incidence of cancer is increasing dramatically, affecting all ages of the population and
reaching an ever higher worldwide mortality rate. The lack of therapies' efficacy is due to …

Background. Due to the molecular heterogeneity of hepatocellular carcinoma (HCC),
majority of patients respond poorly among various of therapy. This study is aimed at …

Pruritus is defined as an unpleasant sensation that elicits a desire to scratch. Nearly a third
of the world's population may suffer from pruritus during their lifetime. This symptom is widely …

Recent studies have highlighted the critical roles of long non-coding RNAs (lncRNAs) in
various biological processes, including but not limited to dosage compensation, epigenetic …

Background Lung adenocarcinoma (LUAD) is one of the major types of lung cancer with
high morbidity and mortality. The TRAF-interacting protein (TRAIP) is a ring-type E3 ubiquitin …

Background: Chemokines not only regulate immune cells but also play significant roles in
development and treatment of tumors and patient prognoses. However, these effects have …

Abstract “Heterogeneity” in tumor mass has immense importance in cancer progression and
therapy. The impact of tumor heterogeneity is an emerging field and not yet fully explored …