Although we have learned much about how the brain fuels its functions over the last
decades, there remains much still to discover in an organ that is so complex. This article lays …

The accumulation of senescent cells drives inflammaging and increases morbidity of chronic
inflammatory lung diseases. Immune responses are built upon dynamic changes in cell …

Microglia are critically involved in post‐stroke inflammation affecting neurological outcomes.
Lipid droplet (LD) accumulation in microglia results in a dysfunctional and pro‐inflammatory …

Ischemic stroke is currently the second leading cause of mortality worldwide, with limited
treatment options available. As resident immune cells, microglia promptly respond to …

Overlaying omics data onto spatial biological dimensions has been a promising technology
to provide high-resolution insights into the interactome and cellular heterogeneity relative to …

Acute ischemic stroke (AIS) triggers immune responses and neuroinflammation, contributing
to brain injury. Histone lactylation, a metabolic stress-related histone modification, plays a …

Current metabolomics technologies can measure hundreds of chemical entities in tissue
extracts with good reliability. However, long-recognized requirements to halt enzyme …

The capacity of immune cells to alter their function based on their metabolism is the basis of
the emerging field of immunometabolism. Microglia are the resident innate immune cells of …

Long-chain acylcarnitines (LCACs) are intermediates of fatty acid oxidation and are known
to exert detrimental effects on mitochondria. This study aimed to test whether lowering LCAC …

Microglia, the resident immune cells of the central nervous system (CNS), play a crucial role
in maintaining tissue homeostasis by monitoring and responding to environmental changes …