The nexus between RNA-binding proteins and their effectors
RNA-binding proteins (RBPs) regulate essentially every event in the lifetime of an RNA
molecule, from its production to its destruction. Whereas much has been learned about RNA …
molecule, from its production to its destruction. Whereas much has been learned about RNA …
Emerging evidence of translational control by AU-rich element-binding proteins
H Otsuka, A Fukao, Y Funakami, KE Duncan… - Frontiers in …, 2019 - frontiersin.org
RNA-binding proteins (RBPs) are key regulators of posttranscriptional gene expression and
control many important biological processes including cell proliferation, development, and …
control many important biological processes including cell proliferation, development, and …
m6A reader YTHDF2 regulates LPS-induced inflammatory response
R Yu, Q Li, Z Feng, L Cai, Q Xu - International Journal of Molecular …, 2019 - mdpi.com
N6-methyladenosine (m6A) is an abundant mRNA modification that affects multiple
biological processes, including those involved in the cell stress response and viral infection …
biological processes, including those involved in the cell stress response and viral infection …
RNA recognition and immunity—innate immune sensing and its posttranscriptional regulation mechanisms
T Uehata, O Takeuchi - Cells, 2020 - mdpi.com
RNA acts as an immunostimulatory molecule in the innate immune system to activate
nucleic acid sensors. It functions as an intermediate, conveying genetic information to …
nucleic acid sensors. It functions as an intermediate, conveying genetic information to …
RNA-binding proteins distinguish between similar sequence motifs to promote targeted deadenylation by Ccr4-Not
The Ccr4-Not complex removes mRNA poly (A) tails to regulate eukaryotic mRNA stability
and translation. RNA-binding proteins contribute to specificity by interacting with both Ccr4 …
and translation. RNA-binding proteins contribute to specificity by interacting with both Ccr4 …
Reconstitution of recombinant human CCR4-NOT reveals molecular insights into regulated deadenylation
CCR4-NOT is a conserved multiprotein complex which regulates eukaryotic gene
expression principally via shortening of poly (A) tails of messenger RNA or deadenylation …
expression principally via shortening of poly (A) tails of messenger RNA or deadenylation …
4E-T-bound mRNAs are stored in a silenced and deadenylated form
F Räsch, R Weber, E Izaurralde… - Genes & …, 2020 - genesdev.cshlp.org
Human 4E-T is an eIF4E-binding protein (4E-BP) present in processing (P)-bodies that
represses translation and regulates decay of mRNAs destabilized by AU-rich elements and …
represses translation and regulates decay of mRNAs destabilized by AU-rich elements and …
N6-Adenosine Methylation (m6A) RNA Modification: an Emerging Role in Cardiovascular Diseases
Y Chen, X Ouyang, X Yu, P Novák, L Zhou… - Journal of …, 2021 - Springer
Abstract N6-methyladenosine (m 6 A) is the most abundant and prevalent epigenetic
modification of mRNA in mammals. This dynamic modification is regulated by m 6 A …
modification of mRNA in mammals. This dynamic modification is regulated by m 6 A …
RNF219 attenuates global mRNA decay through inhibition of CCR4-NOT complex-mediated deadenylation
The CCR4-NOT complex acts as a central player in the control of mRNA turnover and
mediates accelerated mRNA degradation upon HDAC inhibition. Here, we explored …
mediates accelerated mRNA degradation upon HDAC inhibition. Here, we explored …
Control of immediate early gene expression by CPEB4-repressor complex-mediated mRNA degradation
Background Cytoplasmic polyadenylation element-binding protein 4 (CPEB4) is known to
associate with cytoplasmic polyadenylation elements (CPEs) located in the 3′ untranslated …
associate with cytoplasmic polyadenylation elements (CPEs) located in the 3′ untranslated …