Vascular cognitive impairment (VCI) refers to all forms of cognitive disorder related to
cerebrovascular diseases, including vascular mild cognitive impairment, post-stroke …

Human cortical organoids, three-dimensional neuronal cultures, are emerging as powerful
tools to study brain development and dysfunction. However, whether organoids can …

Deterioration of brain capillary flow and architecture is a hallmark of aging and dementia. It
remains unclear how loss of brain pericytes in these conditions contributes to capillary …

The neurovascular unit (NVU) of the brain is composed of multiple cell types that act
synergistically to modify blood flow to locally match the energy demand of neural activity, as …

Capillary networks are essential for distribution of blood flow through the brain, and
numerous other homeostatic functions, including neurovascular signal conduction and …

Neurovascular coupling links brain activity to local changes in blood flow, forming the basis
for non-invasive brain mapping. Using multiscale imaging, we investigated how vascular …

Blood microcirculation supplies neurons with oxygen and nutrients, and contributes to
clearing their neurotoxic waste, through a dense capillary network connected to larger tree …

Ever since the introduction of thrombolysis and the subsequent expansion of endovascular
treatments for acute ischemic stroke, it remains to be identified why the actual outcomes are …

Perivascular fibroblasts (PVFs) are recognized for their pro-fibrotic role in many central
nervous system disorders. Like mural cells, PVFs surround blood vessels and express …

Aging is a major risk factor for cognitive impairment. Aerobic exercise benefits brain function
and may promote cognitive health in older adults. However, underlying biological …