Cancer is a condition where the body cells multiply in an uncontrollable manner.
Chemoprevention of cancer is a broad term that describes the involvement of external …

The retinoids are a group of compounds including vitamin A and its active metabolite all-
trans-retinoic acid (ATRA). Retinoids regulate a variety of physiological functions in multiple …

Retinoic acid (RA), the major bioactive metabolite of retinol or vitamin A, induces a spectrum
of pleiotropic effects in cell growth and differentiation that are relevant for embryonic …

We characterized the enhancer landscape of 66 patients with acute myeloid leukemia
(AML), identifying 6 novel subgroups and their associated regulatory loci. These subgroups …

Early in the age of modern medicine the consequences of vitamin A deficiency drew
attention to the fundamental link between retinoid-dependent homeostatic regulation and …

Breast cancer is a complex and diverse disease accounting for nearly 30% of all cancers
diagnosed in females. But unfortunately, patients develop resistance to the existing …

Retinol and vitamin A derivatives influence cell differentiation, proliferation, and apoptosis
and play an important physiologic role in a wide range of biological processes. Retinol is …

Vitamin A and carotenoids are fat-soluble micronutrients that play important role as powerful
antioxidants modulating oxidative stress and cancer development. Breast cancer is the most …

Nuclear receptors (NRs) have historically been at the forefront of cancer research, where
they are known to act as critical regulators of disease. They also serve as biomarkers for …

Preclinical, clinical, and epidemiological studies indicate that vitamin D3 (VD) deficiency is a
risk factor for the development of breast cancer. Underlying mechanisms include the ability …