Promising therapeutic aspects in human genetic imprinting disorders

Y Chao, Y Qin, X Zou, X Wang, C Hu, F Xia, C Zou - Clinical Epigenetics, 2022 - Springer
Genomic imprinting is an epigenetic phenomenon of monoallelic gene expression pattern
depending on parental origin. In humans, congenital imprinting disruptions resulting from …

Chromosomal Polymorphism and Speciation: The Case of the Genus Mazama (Cetartiodactyla; Cervidae)

DJ Galindo, GS Martins, M Vozdova, H Cernohorska… - Genes, 2021 - mdpi.com
Chromosomal polymorphism plays a major role in speciation processes in mammals with
high rates of karyotypic evolution, as observed in the family Cervidae. One remarkable …

[HTML][HTML] Paternal Contributions to Recurrent Pregnancy Loss: Mechanisms, Biomarkers, and Therapeutic Approaches

A Kaltsas, A Zikopoulos, V Kojovic, F Dimitriadis… - Medicina, 2024 - mdpi.com
Background and Objectives: Recurrent pregnancy loss (RPL) affects numerous couples
worldwide and has traditionally been attributed mainly to maternal factors. However, recent …

Meiotic heterogeneity of trivalent structure and interchromosomal effect in blastocysts with Robertsonian translocations

S Zhang, C Lei, J Wu, J Zhou, M Xiao, S Zhu, Y Xi… - Frontiers in …, 2021 - frontiersin.org
Background Robertsonian translocations are common structural rearrangements and confer
an increased genetic reproductive risk due to the formation of trivalent structure during …

Swimming trapper decreases the proportion of chromosomally unbalanced spermatozoa in human Robertsonian translocation carriers

XN Liu, MY Li, QL Ma, J Chen, S Liu, Y Yu, L Sun - Andrology, 2024 - Wiley Online Library
Background Carriers of reciprocal translocations often have more unbalanced spermatozoa
and higher DNA fragmentation rates, elevating reproductive risk. The simple swim‐up …

FISH analysis of numerical chromosomal abnormalities in the sperm of robertsonian translocation der (13; 14)(q10; q10) carriers

S Zhu, Y Zhu, F Zhang, J Wu, Y Chen, Y Sun… - Frontiers in …, 2022 - frontiersin.org
Fluorescence in situ hybridization analysis of numerical chromosomal abnormalities in the
sperm of Robertsonian translocation der (13; 14)(q10; q10) carriers has focused on a limited …

[HTML][HTML] Sperm chromosome segregation of rob (4; 16) and rob (4; 16) inv (4) in the brown brocket deer (Mazama gouazoubira)

DJ Galindo, M Vozdova, S Kubickova, H Cernohorska… - Theriogenology, 2021 - Elsevier
The genus Mazama stands out among the Neotropical deer due to their wide intra and
interspecific karyotypic diversification, which is associated with an accentuated …

[HTML][HTML] Homozygosity for Robertsonian Translocation (14q; 15q) in a Newborn with a Familial History of Recurrent Abortion and Newborns Affected by …

S Sahraeean, A Jebelli, Z Shahbazi… - Journal of Reproduction …, 2023 - ncbi.nlm.nih.gov
Background: Robertsonian translocations (RobTs) are one of the major chromosomal
abnormalities which lead to spontaneous abortion. They occur in the human population at …

GENETIC ASPECTS OF AGING AND FERTILITY

D Miteva, T Velikova - Anti-Aging Eastern Europe, 2024 - antiagingeeu.com
As women age, reproductive challenges become more prevalent, including increased
miscarriage rates due to genetic defects, as well as common complications of the pregnancy …

Application of the FISH Method for Analyzing Chromosome Segregation Patterns in Preimplantation Embryos from Robertsonian Translocation Carriers

IL Puppo, ZN Tonyan, AN Panina, KV Shunkina… - OBM Genetics, 2022 - lidsen.com
Robertsonian translocations (RTs) are very common balanced structural chromosome
rearrangements in humans. Due to alterations in the chromosome segregation pattern and …