Peroxisome proliferator-activated receptor γ (PPARγ) is a widely expressed ligand-
modulated transcription factor that governs the expression of genes involved in …

The prevalence of obesity is high among reproductive-age women and is associated with
impaired reproductive function. Obesity is multifactorial in origin, yet many cases of obesity …

Background Rosiglitazone is widely used to treat patients with type 2 diabetes mellitus, but
its effect on cardiovascular morbidity and mortality has not been determined. Methods We …

Autosomal-dominant arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D)
causes sudden cardiac death and is characterized by clinical and genetic heterogeneity …

Although PD-1 blockade cancer immunotherapy has shown potential for a wide range of
patients with cancer, its efficacy is limited, in part, due to the loss of effector cytotoxic T …

Ubiquitous expression of amyotrophic lateral sclerosis (ALS)-causing mutations in
superoxide dismutase 1 (SOD1) provokes noncell autonomous paralytic disease. By …

Dysfunction of invariant natural killer T (iNKT) cells in tumor microenvironment hinders their
anti-tumor efficacy, and the underlying mechanisms remain unclear. Here we report that …

Macrophages (Mφ) are central players in mediating proinflammatory and
immunomodulatory functions. Unchecked Mφ activities contribute to pathology across many …

Pulmonary fibrosis is characterized by alterations in fibroblast phenotypes resulting in
excessive extracellular matrix accumulation and anatomic remodeling. Current therapies for …

Exposure to environmental chemicals adds to the burden of disease in humans and wildlife
to a degree that is difficult to estimate and, thus, mitigate. The ability to assess the impact of …