Influence of genetic polymorphism towards pulmonary tuberculosis susceptibility

M Harishankar, P Selvaraj, R Bethunaickan - Frontiers in medicine, 2018 - frontiersin.org
Tuberculosis (TB) is still remains the major threat for human health worldwide. Several case-
control, candidate-gene, family studies and genome-wide association studies (GWAS) …

Alcohol consumption and risk of tuberculosis: a systematic review and meta-analysis

E Simou, J Britton… - The International Journal of …, 2018 - ingentaconnect.com
OBJECTIVE: To perform a systematic review and meta-analysis of the association between
alcohol consumption and risk of tuberculosis (TB). METHODS: Medline, EMBASE and Web …

Genome-wide host-pathogen analyses reveal genetic interaction points in tuberculosis disease

J Phelan, PJ Gomez-Gonzalez, N Andreu… - Nature …, 2023 - nature.com
The genetics underlying tuberculosis (TB) pathophysiology are poorly understood. Human
genome-wide association studies have failed so far to reveal reproducible susceptibility loci …

Inflammasome genetic variants are associated with tuberculosis, HIV-1 infection, and TB/HIV-immune reconstitution inflammatory syndrome outcomes

NBR de Sá, NCS de Souza, M Neira-Goulart… - Frontiers in Cellular …, 2022 - frontiersin.org
Background Tuberculosis (TB) and AIDS are the leading causes of infectious diseases
death worldwide. Here, we investigated the relationship between from single nucleotide …

Tuberculosis and autoimmunity: Common features

A Starshinova, А Malkova, I Kudryavtsev, D Kudlay… - Tuberculosis, 2022 - Elsevier
Despite the proven infectious nature of tuberculosis, new data have recently appeared on
the autoimmune component in the course of tuberculosis infection. This chapter discusses …

Discovery of susceptibility loci associated with tuberculosis in Han Chinese

H Qi, YB Zhang, L Sun, C Chen, B Xu… - Human Molecular …, 2017 - academic.oup.com
Genome-wide association studies (GWASs) have revealed the worldwide heterogeneity of
genetic factors in tuberculosis (TB) susceptibility. Despite having the third highest global TB …

Genomics of human pulmonary tuberculosis: from genes to pathways

CM Stein, L Sausville, C Wejse, RS Sobota… - … genetic medicine reports, 2017 - Springer
Abstract Purpose of Review Tuberculosis (TB), caused by Mycobacterium tuberculosis
(MTB), remains a major public health threat globally. Several lines of evidence support a …

Expression of specific HLA class II alleles is associated with an increased risk for active tuberculosis and a distinct gene expression profile

LY Chihab, R Kuan, EJ Phillips, SA Mallal, V Rozot… - Hla, 2023 - Wiley Online Library
Several HLA allelic variants have been associated with protection from or susceptibility to
infectious and autoimmune diseases. Here, we examined whether specific HLA alleles …

The Methylation in B7-H4 and BTLA Genes are Associated with the Risk of Pulmonary Tuberculosis

XQ Cai, Q Huang, TP Zhang - ImmunoTargets and Therapy, 2023 - Taylor & Francis
Background The important roles of B7 homologous body 4 (B7-H4), B and T lymphocyte
attenuator (BTLA) in patients with pulmonary tuberculosis (PTB) have been reported. This …

The opposite effect of human leukocyte antigen genotypes in sarcoidosis and tuberculosis: a narrative review of the literature

A Malkova, A Starshinova, Y Zinchenko… - ERJ Open …, 2020 - Eur Respiratory Soc
Sarcoidosis and tuberculosis share several similar clinical and pathogenic characteristics
that make some researchers consider a common pathogenesis for these diseases. Human …