Point mutations cause members of the serine protease inhibitor (serpin) superfamily to
undergo a novel conformational transition, forming ordered polymers. These polymers …

Although conventionally associated with fibrin clot degradation, recent work has uncovered
new functions for the tissue plasminogen activator (tPA)/plasminogen cascade in central …

Gene mutations and gene copy number variants are associated with autism spectrum
disorders (ASDs). Affected gene products are often part of signaling networks implicated in …

It is well established that the proteolytic processing of the β-amyloid precursor protein (APP)
generates β-amyloid (Aβ), which plays a central role in the pathogenesis of Alzheimer's …

The key role of APP in the pathogenesis of Alzheimer disease is well established. However,
postnatal lethality of double knockout mice has so far precluded the analysis of the …

The main source of error in gene expression is messenger RNA decoding by the ribosome.
Translational accuracy has been suggested on a purely correlative basis to positively …

Corticosteroid action in the brain is mediated by the mineralocorticoid (MR) and the
glucocorticoid (GR) receptor. Disturbances in MR-and GR-mediated effects are thought to …

Our research has proven that the inhibitory activity of the serine protease inhibitor
neuroserpin (NS) is impaired because of its oxidation deactivation in glaucoma. Using …

Age-related neurodegenerative diseases (NDDs) are associated with the aggregation and
propagation of specific pathogenic protein species (eg, Aβ, α-synuclein). However, whether …

The present study, examines some issues in the measure and analysis of behavior in
animals. Two strains of rats of both genders were used to illustrate and discuss these issues …