This review addresses recent advances in specific mechanisms of hepatotoxicity. Because
of its unique metabolism and relationship to the gastrointestinal tract, the liver is an important …

Severe and prolonged impairment of mitochondrial β-oxidation leads to microvesicular
steatosis, and, in severe forms, to liver failure, coma and death. Impairment of mitochondrial …

A frequent mechanism for drug-induced liver injury (DILI) is the formation of reactive
metabolites that trigger hepatitis through direct toxicity or immune reactions. Both events …

Cytokines are soluble proteins that allow for communication between cells and the external
environment. Interferon (IFN) alpha, the first cytokine to be produced by recombinant DNA …

Mitochondria are involved in fatty acid β-oxidation, the tricarboxylic acid cycle, and oxidative
phosphorylation, which provide most of the cell energy. Mitochondria are also the main …

It is widely found that the ratio of nitrite consumption to ammonia consumption (ΔNO 2--
N/ΔNH 4+-N) in Anammox systems is lower than its stoichiometry of 1.32, but the reason is …

Background Genetic mitochondrial diseases represent a significant challenge to human
health. These diseases are extraordinarily heterogeneous in clinical presentation and …

Childhood obesity is a serious public health crisis and a critical factor that determines future
obesity prevalence. Signals affecting adipocyte development in early postnatal life have a …

Few human tumors are collected such that RNA is preserved for molecular analysis.
Completion of the Human Genome Project will soon result in the identification of more than …

Featuring more than 4100 references, Drug-Induced Liver Disease is an invaluable
reference for gastroenterologists, hepatologists, family physicians, internists, pathologists …