Target of Rapamycin (TOR) is an atypical Ser/Thr protein kinase that is evolutionally
conserved among yeasts, plants, and mammals. In plants, TOR signaling functions as a …

Alopecia areata (AA) is characterized by common non-scarring alopecia due to autoimmune
disorders. To date, the specific pathogenesis underlying AA remains unknown. Thus, AA …

Elongation factor TFIIS (transcription factor IIS) is structurally and biochemically probably the
best characterized elongation cofactor of RNA polymerase II. However, little is known about …

Ultraviolet (UV) light is a natural genotoxic agent leading to the formation of photolesions
endangering the genomic integrity and thereby the survival of living organisms. To prevent …

Although solar light is indispensable for the functioning of plants, this environmental factor
may also cause damage to living cells. Apart from the visible range, including wavelengths …

In eukaryotes, general transcription factors (GTFs) enable recruitment of RNA polymerase II
(RNA Pol II) to core promoters to facilitate initiation of transcription. Extensive research in …

Previous work with the classic T4 endonuclease V digestion of DNA from irradiated
Drosophila cells followed by Southern hybridization led to the conclusion that Drosophila …

Tumor necrosis factor receptor‐associated factor (TRAF) proteins are conserved in higher
eukaryotes and play key roles in transducing cellular signals across different organelles …

Ubiquitination is a highly conserved and dynamic post-translational modification in which
protein substrates are modified by ubiquitin to influence their activity, localization, or stability …

Abstract N6-methyladenosine (m6A) is the most common and prevalent internal mRNA
modification in eukaryotes. m6A modification is a dynamic and reversible process regulated …